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The development of ZnO nanoparticle-embedded graphitic-carbon nitride towards triple-negative breast cancer therapy
The present study deals with the effects of curcumin-loaded ZnO nanoparticles (NPs) embedded in graphitic-carbon nitride (g-C(3)N(4)) sheets for breast cancer cells. The synthesis of these sheets was carried out by a simple co-precipitation method. The physicochemical and thermal properties of the c...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424565/ https://www.ncbi.nlm.nih.gov/pubmed/37583658 http://dx.doi.org/10.1039/d3ra02887a |
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author | Padmanabhan, Varun Prasath Sivashanmugam, Pugalmani S. M., Mubashera Sagadevan, Suresh Kulandaivelu, Ravichandran |
author_facet | Padmanabhan, Varun Prasath Sivashanmugam, Pugalmani S. M., Mubashera Sagadevan, Suresh Kulandaivelu, Ravichandran |
author_sort | Padmanabhan, Varun Prasath |
collection | PubMed |
description | The present study deals with the effects of curcumin-loaded ZnO nanoparticles (NPs) embedded in graphitic-carbon nitride (g-C(3)N(4)) sheets for breast cancer cells. The synthesis of these sheets was carried out by a simple co-precipitation method. The physicochemical and thermal properties of the composite sheets were studied using various characterization techniques. The powder X-ray diffraction and high-resolution transmission electron microscopy analyses confirmed the hexagonal wurtzite phase of the ZnO nanoparticles, which were randomly distributed on the g-C(3)N(4) nanosheets, generating a finely bonded interface between the two components. The X-ray photoelectron spectroscopy analysis confirmed the successful formation of the g-C(3)N(4)@ZnO composite, while the thermal studies revealed the thermal stability of the composite. In addition, the drug release and kinetics studies proved that the release of curcumin was more significant under acidic conditions (pH 5) compared with neutral pH (7.4). Further, the biological assays verified the antibacterial activity (against two different cultures of E. coli and S. aureus) and anticancer activity (against MDA-MB-231 cancer cells) of the g-C(3)N(4)@ZnO/C nanocomposite. Finally, the lactate dehydrogenase activity assay presented the cytotoxic assessment of the nanocomposite based on its cytoplasmic activity and the extent of enzymes released from the damaged cells. |
format | Online Article Text |
id | pubmed-10424565 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-104245652023-08-15 The development of ZnO nanoparticle-embedded graphitic-carbon nitride towards triple-negative breast cancer therapy Padmanabhan, Varun Prasath Sivashanmugam, Pugalmani S. M., Mubashera Sagadevan, Suresh Kulandaivelu, Ravichandran RSC Adv Chemistry The present study deals with the effects of curcumin-loaded ZnO nanoparticles (NPs) embedded in graphitic-carbon nitride (g-C(3)N(4)) sheets for breast cancer cells. The synthesis of these sheets was carried out by a simple co-precipitation method. The physicochemical and thermal properties of the composite sheets were studied using various characterization techniques. The powder X-ray diffraction and high-resolution transmission electron microscopy analyses confirmed the hexagonal wurtzite phase of the ZnO nanoparticles, which were randomly distributed on the g-C(3)N(4) nanosheets, generating a finely bonded interface between the two components. The X-ray photoelectron spectroscopy analysis confirmed the successful formation of the g-C(3)N(4)@ZnO composite, while the thermal studies revealed the thermal stability of the composite. In addition, the drug release and kinetics studies proved that the release of curcumin was more significant under acidic conditions (pH 5) compared with neutral pH (7.4). Further, the biological assays verified the antibacterial activity (against two different cultures of E. coli and S. aureus) and anticancer activity (against MDA-MB-231 cancer cells) of the g-C(3)N(4)@ZnO/C nanocomposite. Finally, the lactate dehydrogenase activity assay presented the cytotoxic assessment of the nanocomposite based on its cytoplasmic activity and the extent of enzymes released from the damaged cells. The Royal Society of Chemistry 2023-08-14 /pmc/articles/PMC10424565/ /pubmed/37583658 http://dx.doi.org/10.1039/d3ra02887a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Padmanabhan, Varun Prasath Sivashanmugam, Pugalmani S. M., Mubashera Sagadevan, Suresh Kulandaivelu, Ravichandran The development of ZnO nanoparticle-embedded graphitic-carbon nitride towards triple-negative breast cancer therapy |
title | The development of ZnO nanoparticle-embedded graphitic-carbon nitride towards triple-negative breast cancer therapy |
title_full | The development of ZnO nanoparticle-embedded graphitic-carbon nitride towards triple-negative breast cancer therapy |
title_fullStr | The development of ZnO nanoparticle-embedded graphitic-carbon nitride towards triple-negative breast cancer therapy |
title_full_unstemmed | The development of ZnO nanoparticle-embedded graphitic-carbon nitride towards triple-negative breast cancer therapy |
title_short | The development of ZnO nanoparticle-embedded graphitic-carbon nitride towards triple-negative breast cancer therapy |
title_sort | development of zno nanoparticle-embedded graphitic-carbon nitride towards triple-negative breast cancer therapy |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424565/ https://www.ncbi.nlm.nih.gov/pubmed/37583658 http://dx.doi.org/10.1039/d3ra02887a |
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