Cargando…
An Adjustable Magnetic Levator Prosthesis for Customizable Eyelid Re-Animation in Severe Blepharoptosis: Design and Proof-of-Concept
PURPOSE: Blepharoptosis is a common oculoplastic condition causing incomplete opening of the upper eyelid. Surgical approaches, the mainstay for correction, often fail to improve blink function. The purpose of this study was to develop a nonsurgical treatment option for severe ptosis that allows bli...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Association for Research in Vision and Ophthalmology
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424798/ https://www.ncbi.nlm.nih.gov/pubmed/37566397 http://dx.doi.org/10.1167/tvst.12.8.11 |
_version_ | 1785089740968558592 |
---|---|
author | Kurukuti, Nish Mohith Nadeau, Melanie Paschalis, Eleftherios I. Houston, Kevin E. |
author_facet | Kurukuti, Nish Mohith Nadeau, Melanie Paschalis, Eleftherios I. Houston, Kevin E. |
author_sort | Kurukuti, Nish Mohith |
collection | PubMed |
description | PURPOSE: Blepharoptosis is a common oculoplastic condition causing incomplete opening of the upper eyelid. Surgical approaches, the mainstay for correction, often fail to improve blink function. The purpose of this study was to develop a nonsurgical treatment option for severe ptosis that allows blink re-animation. METHODS: Magnetic force required to perform blink re-animation was characterized by evaluation of eye-opening and closing using inter-palpebral fissure (IPF) outcomes with various combinations of eyelid array and box magnets. Optimal size of the spectacle magnet that achieved forces required for optimal blink dynamics was selected using simulation. The adjustable magnetic levator prosthesis (aMLP) included an eyelid array magnet and an adjustable rotating spectacle magnet that allowed change in the magnetic direction, thus changing the net magnetic interactive force between the magnets. The clinical feasibility of aMLP in improving eye opening without limiting eye closing was evaluated in patients with ptosis through a proof-of-concept study using IPF and comfort outcomes. RESULTS: Optimal eye opening and closing was achieved by a magnet-array combination providing 45 grams of surface force (gF) in the tested ptosis population. The aMLP was able to modulate eye opening and closing with change in rotation of the spectacle magnet in two patients with ptotis. The best fitting of an aMLP improved IPF opening without limiting eye closing and with good comfort reported. CONCLUSIONS: Preliminary results suggest that the an aMLP can correct ptosis without adversely affecting blink function. Further evaluation in a larger patient population is warranted. TRANSLATIONAL RELEVANCE: A nonsurgical, proof of concept, adjustable magnetic treatment option for blink re-animation in patients with severe ptosis is presented. |
format | Online Article Text |
id | pubmed-10424798 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Association for Research in Vision and Ophthalmology |
record_format | MEDLINE/PubMed |
spelling | pubmed-104247982023-08-15 An Adjustable Magnetic Levator Prosthesis for Customizable Eyelid Re-Animation in Severe Blepharoptosis: Design and Proof-of-Concept Kurukuti, Nish Mohith Nadeau, Melanie Paschalis, Eleftherios I. Houston, Kevin E. Transl Vis Sci Technol Low Vision Rehabilitation PURPOSE: Blepharoptosis is a common oculoplastic condition causing incomplete opening of the upper eyelid. Surgical approaches, the mainstay for correction, often fail to improve blink function. The purpose of this study was to develop a nonsurgical treatment option for severe ptosis that allows blink re-animation. METHODS: Magnetic force required to perform blink re-animation was characterized by evaluation of eye-opening and closing using inter-palpebral fissure (IPF) outcomes with various combinations of eyelid array and box magnets. Optimal size of the spectacle magnet that achieved forces required for optimal blink dynamics was selected using simulation. The adjustable magnetic levator prosthesis (aMLP) included an eyelid array magnet and an adjustable rotating spectacle magnet that allowed change in the magnetic direction, thus changing the net magnetic interactive force between the magnets. The clinical feasibility of aMLP in improving eye opening without limiting eye closing was evaluated in patients with ptosis through a proof-of-concept study using IPF and comfort outcomes. RESULTS: Optimal eye opening and closing was achieved by a magnet-array combination providing 45 grams of surface force (gF) in the tested ptosis population. The aMLP was able to modulate eye opening and closing with change in rotation of the spectacle magnet in two patients with ptotis. The best fitting of an aMLP improved IPF opening without limiting eye closing and with good comfort reported. CONCLUSIONS: Preliminary results suggest that the an aMLP can correct ptosis without adversely affecting blink function. Further evaluation in a larger patient population is warranted. TRANSLATIONAL RELEVANCE: A nonsurgical, proof of concept, adjustable magnetic treatment option for blink re-animation in patients with severe ptosis is presented. The Association for Research in Vision and Ophthalmology 2023-08-11 /pmc/articles/PMC10424798/ /pubmed/37566397 http://dx.doi.org/10.1167/tvst.12.8.11 Text en Copyright 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
spellingShingle | Low Vision Rehabilitation Kurukuti, Nish Mohith Nadeau, Melanie Paschalis, Eleftherios I. Houston, Kevin E. An Adjustable Magnetic Levator Prosthesis for Customizable Eyelid Re-Animation in Severe Blepharoptosis: Design and Proof-of-Concept |
title | An Adjustable Magnetic Levator Prosthesis for Customizable Eyelid Re-Animation in Severe Blepharoptosis: Design and Proof-of-Concept |
title_full | An Adjustable Magnetic Levator Prosthesis for Customizable Eyelid Re-Animation in Severe Blepharoptosis: Design and Proof-of-Concept |
title_fullStr | An Adjustable Magnetic Levator Prosthesis for Customizable Eyelid Re-Animation in Severe Blepharoptosis: Design and Proof-of-Concept |
title_full_unstemmed | An Adjustable Magnetic Levator Prosthesis for Customizable Eyelid Re-Animation in Severe Blepharoptosis: Design and Proof-of-Concept |
title_short | An Adjustable Magnetic Levator Prosthesis for Customizable Eyelid Re-Animation in Severe Blepharoptosis: Design and Proof-of-Concept |
title_sort | adjustable magnetic levator prosthesis for customizable eyelid re-animation in severe blepharoptosis: design and proof-of-concept |
topic | Low Vision Rehabilitation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424798/ https://www.ncbi.nlm.nih.gov/pubmed/37566397 http://dx.doi.org/10.1167/tvst.12.8.11 |
work_keys_str_mv | AT kurukutinishmohith anadjustablemagneticlevatorprosthesisforcustomizableeyelidreanimationinsevereblepharoptosisdesignandproofofconcept AT nadeaumelanie anadjustablemagneticlevatorprosthesisforcustomizableeyelidreanimationinsevereblepharoptosisdesignandproofofconcept AT paschaliseleftheriosi anadjustablemagneticlevatorprosthesisforcustomizableeyelidreanimationinsevereblepharoptosisdesignandproofofconcept AT houstonkevine anadjustablemagneticlevatorprosthesisforcustomizableeyelidreanimationinsevereblepharoptosisdesignandproofofconcept AT kurukutinishmohith adjustablemagneticlevatorprosthesisforcustomizableeyelidreanimationinsevereblepharoptosisdesignandproofofconcept AT nadeaumelanie adjustablemagneticlevatorprosthesisforcustomizableeyelidreanimationinsevereblepharoptosisdesignandproofofconcept AT paschaliseleftheriosi adjustablemagneticlevatorprosthesisforcustomizableeyelidreanimationinsevereblepharoptosisdesignandproofofconcept AT houstonkevine adjustablemagneticlevatorprosthesisforcustomizableeyelidreanimationinsevereblepharoptosisdesignandproofofconcept |