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Developments in (177)Lu-based radiopharmaceutical therapy and dosimetry

(177)Lu is a radioisotope that has become increasingly popular as a therapeutic agent for treating various conditions, including neuroendocrine tumors and metastatic prostate cancer. (177)Lu-tagged radioligands are molecules precisely designed to target and bind to specific receptors or proteins cha...

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Detalles Bibliográficos
Autores principales: George, Siju C., Samuel, E. James Jebaseelan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10424930/
https://www.ncbi.nlm.nih.gov/pubmed/37583569
http://dx.doi.org/10.3389/fchem.2023.1218670
Descripción
Sumario:(177)Lu is a radioisotope that has become increasingly popular as a therapeutic agent for treating various conditions, including neuroendocrine tumors and metastatic prostate cancer. (177)Lu-tagged radioligands are molecules precisely designed to target and bind to specific receptors or proteins characteristic of targeted cancer. This review paper will present an overview of the available (177)Lu-labelled radioligands currently used to treat patients. Based on recurring, active, and completed clinical trials and other available literature, we evaluate current status, interests, and developments in assessing patient-specific dosimetry, which will define the future of this particular treatment modality. In addition, we will discuss the challenges and opportunities of the existing dosimetry standards to measure and calculate the radiation dose delivered to patients, which is essential for ensuring treatments’ safety and efficacy. Finally, this article intends to provide an overview of the current state of (177)Lu- tagged radioligand therapy and highlight the areas where further research can improve patient treatment outcomes.