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No evidence from complementary data sources of a direct glutamatergic projection from the mouse anterior cingulate area to the hippocampal formation

The connectivity and interplay between the prefrontal cortex and hippocampus underpin various key cognitive processes, with changes in these interactions being implicated in both neurodevelopmental and neurodegenerative conditions. Understanding the precise cellular connections through which this ci...

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Autores principales: Andrianova, Lilya, Yanakieva, Steliana, Margetts-Smith, Gabriella, Kohli, Shivali, Brady, Erica S, Aggleton, John P, Craig, Michael T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425170/
https://www.ncbi.nlm.nih.gov/pubmed/37545394
http://dx.doi.org/10.7554/eLife.77364
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author Andrianova, Lilya
Yanakieva, Steliana
Margetts-Smith, Gabriella
Kohli, Shivali
Brady, Erica S
Aggleton, John P
Craig, Michael T
author_facet Andrianova, Lilya
Yanakieva, Steliana
Margetts-Smith, Gabriella
Kohli, Shivali
Brady, Erica S
Aggleton, John P
Craig, Michael T
author_sort Andrianova, Lilya
collection PubMed
description The connectivity and interplay between the prefrontal cortex and hippocampus underpin various key cognitive processes, with changes in these interactions being implicated in both neurodevelopmental and neurodegenerative conditions. Understanding the precise cellular connections through which this circuit is organised is, therefore, vital for understanding these same processes. Overturning earlier findings, a recent study described a novel excitatory projection from anterior cingulate area to dorsal hippocampus. We sought to validate this unexpected finding using multiple, complementary methods: anterograde and retrograde anatomical tracing, using anterograde and retrograde adeno-associated viral vectors, monosynaptic rabies tracing, and the Fast Blue classical tracer. Additionally, an extensive data search of the Allen Projection Brain Atlas database was conducted to find the stated projection within any of the deposited anatomical studies as an independent verification of our own results. However, we failed to find any evidence of a direct, monosynaptic glutamatergic projection from mouse anterior cingulate cortex to the hippocampus proper.
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spelling pubmed-104251702023-08-15 No evidence from complementary data sources of a direct glutamatergic projection from the mouse anterior cingulate area to the hippocampal formation Andrianova, Lilya Yanakieva, Steliana Margetts-Smith, Gabriella Kohli, Shivali Brady, Erica S Aggleton, John P Craig, Michael T eLife Neuroscience The connectivity and interplay between the prefrontal cortex and hippocampus underpin various key cognitive processes, with changes in these interactions being implicated in both neurodevelopmental and neurodegenerative conditions. Understanding the precise cellular connections through which this circuit is organised is, therefore, vital for understanding these same processes. Overturning earlier findings, a recent study described a novel excitatory projection from anterior cingulate area to dorsal hippocampus. We sought to validate this unexpected finding using multiple, complementary methods: anterograde and retrograde anatomical tracing, using anterograde and retrograde adeno-associated viral vectors, monosynaptic rabies tracing, and the Fast Blue classical tracer. Additionally, an extensive data search of the Allen Projection Brain Atlas database was conducted to find the stated projection within any of the deposited anatomical studies as an independent verification of our own results. However, we failed to find any evidence of a direct, monosynaptic glutamatergic projection from mouse anterior cingulate cortex to the hippocampus proper. eLife Sciences Publications, Ltd 2023-08-07 /pmc/articles/PMC10425170/ /pubmed/37545394 http://dx.doi.org/10.7554/eLife.77364 Text en © 2023, Andrianova et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Andrianova, Lilya
Yanakieva, Steliana
Margetts-Smith, Gabriella
Kohli, Shivali
Brady, Erica S
Aggleton, John P
Craig, Michael T
No evidence from complementary data sources of a direct glutamatergic projection from the mouse anterior cingulate area to the hippocampal formation
title No evidence from complementary data sources of a direct glutamatergic projection from the mouse anterior cingulate area to the hippocampal formation
title_full No evidence from complementary data sources of a direct glutamatergic projection from the mouse anterior cingulate area to the hippocampal formation
title_fullStr No evidence from complementary data sources of a direct glutamatergic projection from the mouse anterior cingulate area to the hippocampal formation
title_full_unstemmed No evidence from complementary data sources of a direct glutamatergic projection from the mouse anterior cingulate area to the hippocampal formation
title_short No evidence from complementary data sources of a direct glutamatergic projection from the mouse anterior cingulate area to the hippocampal formation
title_sort no evidence from complementary data sources of a direct glutamatergic projection from the mouse anterior cingulate area to the hippocampal formation
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425170/
https://www.ncbi.nlm.nih.gov/pubmed/37545394
http://dx.doi.org/10.7554/eLife.77364
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