Reduction of nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43–related neurodegeneration

Protein aggregation is a hallmark of many neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). Although mutations in TARDBP, encoding transactive response DNA-binding protein 43 kDa (TDP-43), account for less than 1% of all ALS cases, TDP-43–positive aggregates are present in...

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Detalles Bibliográficos
Autores principales: Tejwani, Leon, Jung, Youngseob, Kokubu, Hiroshi, Sowmithra, Sowmithra, Ni, Luhan, Lee, Changwoo, Sanders, Benjamin, Lee, Paul J., Xiang, Yangfei, Luttik, Kimberly, Soriano, Armand, Yoon, Jennifer, Park, Junhyun, Ro, Hannah H., Ju, Hyoungseok, Liao, Clara, Tieze, Sofia Massaro, Rigo, Frank, Jafar-Nejad, Paymaan, Lim, Janghoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425213/
https://www.ncbi.nlm.nih.gov/pubmed/37384409
http://dx.doi.org/10.1172/JCI138207

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