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Cotargeting a MYC/eIF4A-survival axis improves the efficacy of KRAS inhibitors in lung cancer
Despite the success of KRAS G12C inhibitors in non–small cell lung cancer (NSCLC), more effective treatments are needed. One preclinical strategy has been to cotarget RAS and mTOR pathways; however, toxicity due to broad mTOR inhibition has limited its utility. Therefore, we sought to develop a more...
Autores principales: | Nardi, Francesca, Perurena, Naiara, Schade, Amy E., Li, Ze-Hua, Ngo, Kenneth, Ivanova, Elena V., Saldanha, Aisha, Li, Chendi, Gokhale, Prafulla C., Hata, Aaron N., Barbie, David A., Paweletz, Cloud P., Jänne, Pasi A., Cichowski, Karen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425214/ https://www.ncbi.nlm.nih.gov/pubmed/37384411 http://dx.doi.org/10.1172/JCI167651 |
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