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Temporal trends of sepsis-related mortality in China, 2006–2020: a population-based study

BACKGROUND: The scarcity of sepsis epidemiologic data from most low- and middle-income countries (LMICs) hampered estimation of regional and global burden of the disease, and provided limited guidance for policy makers. We aimed to characterize and analyze the temporal trends of sepsis-related morta...

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Autores principales: Dong, Run, Liu, Wei, Weng, Li, Yin, Peng, Peng, Jinmin, Chen, Yan, Li, Shan, Wang, Chunyao, Jiang, Wei, Hu, Xiaoyun, Du, Bin, Zhou, Maigeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425320/
https://www.ncbi.nlm.nih.gov/pubmed/37578609
http://dx.doi.org/10.1186/s13613-023-01166-1
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author Dong, Run
Liu, Wei
Weng, Li
Yin, Peng
Peng, Jinmin
Chen, Yan
Li, Shan
Wang, Chunyao
Jiang, Wei
Hu, Xiaoyun
Du, Bin
Zhou, Maigeng
author_facet Dong, Run
Liu, Wei
Weng, Li
Yin, Peng
Peng, Jinmin
Chen, Yan
Li, Shan
Wang, Chunyao
Jiang, Wei
Hu, Xiaoyun
Du, Bin
Zhou, Maigeng
author_sort Dong, Run
collection PubMed
description BACKGROUND: The scarcity of sepsis epidemiologic data from most low- and middle-income countries (LMICs) hampered estimation of regional and global burden of the disease, and provided limited guidance for policy makers. We aimed to characterize and analyze the temporal trends of sepsis-related mortality in China, by population groups, underlying causes of death, geographic regions, and sociodemographic index (SDI) levels. METHODS: Sepsis-related deaths were identified from the National Mortality Surveillance System (NMSS) of China from 2006 to 2020. Trends of sepsis-related mortality and years of life lost (YLLs), stratified by age, sex, underlying diseases, and regions were analyzed using the Jointpoint regression analysis. We investigated the association of SDI with trends of sepsis-related mortality. RESULTS: In 2020, sepsis was estimated to be responsible for 986,929 deaths and 17.1 million YLLs in China. Age-standardized sepsis-related mortality significantly declined from 130.2 (95%CI, 129.4–131) per 100,000 population in 2006 to 76.6 (76.3–76.9) in 2020. Age-standardized YLLs decreased from 2172.7 (2169.4–2176) per 100,000 population in 2006 to 1271 (1269.8–1272.2) in 2020. Substantial variations of sepsis-related mortality and YLLs were observed between population groups and regions, with higher burden in males, the elderly, and western China. An inverse relation was noted between SDI and sepsis-related mortality or YLLs. CONCLUSIONS: Despite declining trends of age-standardized mortality and YLLs of sepsis in China, significant disparities between population groups and regions highlight a need for targeted policies and measures to close the gaps and improve the outcome of sepsis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13613-023-01166-1.
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spelling pubmed-104253202023-08-16 Temporal trends of sepsis-related mortality in China, 2006–2020: a population-based study Dong, Run Liu, Wei Weng, Li Yin, Peng Peng, Jinmin Chen, Yan Li, Shan Wang, Chunyao Jiang, Wei Hu, Xiaoyun Du, Bin Zhou, Maigeng Ann Intensive Care Research BACKGROUND: The scarcity of sepsis epidemiologic data from most low- and middle-income countries (LMICs) hampered estimation of regional and global burden of the disease, and provided limited guidance for policy makers. We aimed to characterize and analyze the temporal trends of sepsis-related mortality in China, by population groups, underlying causes of death, geographic regions, and sociodemographic index (SDI) levels. METHODS: Sepsis-related deaths were identified from the National Mortality Surveillance System (NMSS) of China from 2006 to 2020. Trends of sepsis-related mortality and years of life lost (YLLs), stratified by age, sex, underlying diseases, and regions were analyzed using the Jointpoint regression analysis. We investigated the association of SDI with trends of sepsis-related mortality. RESULTS: In 2020, sepsis was estimated to be responsible for 986,929 deaths and 17.1 million YLLs in China. Age-standardized sepsis-related mortality significantly declined from 130.2 (95%CI, 129.4–131) per 100,000 population in 2006 to 76.6 (76.3–76.9) in 2020. Age-standardized YLLs decreased from 2172.7 (2169.4–2176) per 100,000 population in 2006 to 1271 (1269.8–1272.2) in 2020. Substantial variations of sepsis-related mortality and YLLs were observed between population groups and regions, with higher burden in males, the elderly, and western China. An inverse relation was noted between SDI and sepsis-related mortality or YLLs. CONCLUSIONS: Despite declining trends of age-standardized mortality and YLLs of sepsis in China, significant disparities between population groups and regions highlight a need for targeted policies and measures to close the gaps and improve the outcome of sepsis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13613-023-01166-1. Springer International Publishing 2023-08-14 /pmc/articles/PMC10425320/ /pubmed/37578609 http://dx.doi.org/10.1186/s13613-023-01166-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Dong, Run
Liu, Wei
Weng, Li
Yin, Peng
Peng, Jinmin
Chen, Yan
Li, Shan
Wang, Chunyao
Jiang, Wei
Hu, Xiaoyun
Du, Bin
Zhou, Maigeng
Temporal trends of sepsis-related mortality in China, 2006–2020: a population-based study
title Temporal trends of sepsis-related mortality in China, 2006–2020: a population-based study
title_full Temporal trends of sepsis-related mortality in China, 2006–2020: a population-based study
title_fullStr Temporal trends of sepsis-related mortality in China, 2006–2020: a population-based study
title_full_unstemmed Temporal trends of sepsis-related mortality in China, 2006–2020: a population-based study
title_short Temporal trends of sepsis-related mortality in China, 2006–2020: a population-based study
title_sort temporal trends of sepsis-related mortality in china, 2006–2020: a population-based study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425320/
https://www.ncbi.nlm.nih.gov/pubmed/37578609
http://dx.doi.org/10.1186/s13613-023-01166-1
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