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The causal effects of leisure screen time on irritable bowel syndrome risk from a Mendelian randomization study
Associations between leisure sedentary behavior (especially leisure screen time, LST) and irritable bowel syndrome (IBS) have been reported, but causality is unclear. Here, the two-sample Mendelian randomization was performed to investigate the causal association between LST and IBS. Two recently pu...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425325/ https://www.ncbi.nlm.nih.gov/pubmed/37580432 http://dx.doi.org/10.1038/s41598-023-40153-1 |
Sumario: | Associations between leisure sedentary behavior (especially leisure screen time, LST) and irritable bowel syndrome (IBS) have been reported, but causality is unclear. Here, the two-sample Mendelian randomization was performed to investigate the causal association between LST and IBS. Two recently published genome-wide association studies (GWASs) including a total of 1,190,502 people from Europe were used as our data source. Inverse variance weighting (OR = 1.120, 95% CI 1.029–1.219) and weighted median (OR = 1.112, 95% CI 1.000–1.236) analyses revealed a causal effect between LST and IBS. There was no evidence of pleiotropy in the sensitive analysis (MR-Egger, p = 0.139). After removing potentially confounding single nucleotide polymorphisms (SNPs), similar results were found using inverse variance weighting (OR = 1.131, 95% CI 1.025–1.248) and weighted median (OR = 1.151, 95% CI 1.020–1.299), as well as in the validation analyses using inverse variance weighting (OR = 1.287, 95% CI 0.996–1.662). This study provided support for a possible causal relationship between leisure screen time and IBS. |
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