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The role of macrophage ion channels in the progression of atherosclerosis

Atherosclerosis is a complex inflammatory disease that affects the arteries and can lead to severe complications such as heart attack and stroke. Macrophages, a type of immune cell, play a crucial role in atherosclerosis initiation and progression. Emerging studies revealed that ion channels regulat...

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Detalles Bibliográficos
Autores principales: Wu, Xin, Singla, Sidhant, Liu, Jianhua J., Hong, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425548/
https://www.ncbi.nlm.nih.gov/pubmed/37588590
http://dx.doi.org/10.3389/fimmu.2023.1225178
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author Wu, Xin
Singla, Sidhant
Liu, Jianhua J.
Hong, Liang
author_facet Wu, Xin
Singla, Sidhant
Liu, Jianhua J.
Hong, Liang
author_sort Wu, Xin
collection PubMed
description Atherosclerosis is a complex inflammatory disease that affects the arteries and can lead to severe complications such as heart attack and stroke. Macrophages, a type of immune cell, play a crucial role in atherosclerosis initiation and progression. Emerging studies revealed that ion channels regulate macrophage activation, polarization, phagocytosis, and cytokine secretion. Moreover, macrophage ion channel dysfunction is implicated in macrophage-derived foam cell formation and atherogenesis. In this context, exploring the regulatory role of ion channels in macrophage function and their impacts on the progression of atherosclerosis emerges as a promising avenue for research. Studies in the field will provide insights into novel therapeutic targets for the treatment of atherosclerosis.
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spelling pubmed-104255482023-08-16 The role of macrophage ion channels in the progression of atherosclerosis Wu, Xin Singla, Sidhant Liu, Jianhua J. Hong, Liang Front Immunol Immunology Atherosclerosis is a complex inflammatory disease that affects the arteries and can lead to severe complications such as heart attack and stroke. Macrophages, a type of immune cell, play a crucial role in atherosclerosis initiation and progression. Emerging studies revealed that ion channels regulate macrophage activation, polarization, phagocytosis, and cytokine secretion. Moreover, macrophage ion channel dysfunction is implicated in macrophage-derived foam cell formation and atherogenesis. In this context, exploring the regulatory role of ion channels in macrophage function and their impacts on the progression of atherosclerosis emerges as a promising avenue for research. Studies in the field will provide insights into novel therapeutic targets for the treatment of atherosclerosis. Frontiers Media S.A. 2023-07-31 /pmc/articles/PMC10425548/ /pubmed/37588590 http://dx.doi.org/10.3389/fimmu.2023.1225178 Text en Copyright © 2023 Wu, Singla, Liu and Hong https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wu, Xin
Singla, Sidhant
Liu, Jianhua J.
Hong, Liang
The role of macrophage ion channels in the progression of atherosclerosis
title The role of macrophage ion channels in the progression of atherosclerosis
title_full The role of macrophage ion channels in the progression of atherosclerosis
title_fullStr The role of macrophage ion channels in the progression of atherosclerosis
title_full_unstemmed The role of macrophage ion channels in the progression of atherosclerosis
title_short The role of macrophage ion channels in the progression of atherosclerosis
title_sort role of macrophage ion channels in the progression of atherosclerosis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425548/
https://www.ncbi.nlm.nih.gov/pubmed/37588590
http://dx.doi.org/10.3389/fimmu.2023.1225178
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