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The role of macrophage ion channels in the progression of atherosclerosis
Atherosclerosis is a complex inflammatory disease that affects the arteries and can lead to severe complications such as heart attack and stroke. Macrophages, a type of immune cell, play a crucial role in atherosclerosis initiation and progression. Emerging studies revealed that ion channels regulat...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425548/ https://www.ncbi.nlm.nih.gov/pubmed/37588590 http://dx.doi.org/10.3389/fimmu.2023.1225178 |
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author | Wu, Xin Singla, Sidhant Liu, Jianhua J. Hong, Liang |
author_facet | Wu, Xin Singla, Sidhant Liu, Jianhua J. Hong, Liang |
author_sort | Wu, Xin |
collection | PubMed |
description | Atherosclerosis is a complex inflammatory disease that affects the arteries and can lead to severe complications such as heart attack and stroke. Macrophages, a type of immune cell, play a crucial role in atherosclerosis initiation and progression. Emerging studies revealed that ion channels regulate macrophage activation, polarization, phagocytosis, and cytokine secretion. Moreover, macrophage ion channel dysfunction is implicated in macrophage-derived foam cell formation and atherogenesis. In this context, exploring the regulatory role of ion channels in macrophage function and their impacts on the progression of atherosclerosis emerges as a promising avenue for research. Studies in the field will provide insights into novel therapeutic targets for the treatment of atherosclerosis. |
format | Online Article Text |
id | pubmed-10425548 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104255482023-08-16 The role of macrophage ion channels in the progression of atherosclerosis Wu, Xin Singla, Sidhant Liu, Jianhua J. Hong, Liang Front Immunol Immunology Atherosclerosis is a complex inflammatory disease that affects the arteries and can lead to severe complications such as heart attack and stroke. Macrophages, a type of immune cell, play a crucial role in atherosclerosis initiation and progression. Emerging studies revealed that ion channels regulate macrophage activation, polarization, phagocytosis, and cytokine secretion. Moreover, macrophage ion channel dysfunction is implicated in macrophage-derived foam cell formation and atherogenesis. In this context, exploring the regulatory role of ion channels in macrophage function and their impacts on the progression of atherosclerosis emerges as a promising avenue for research. Studies in the field will provide insights into novel therapeutic targets for the treatment of atherosclerosis. Frontiers Media S.A. 2023-07-31 /pmc/articles/PMC10425548/ /pubmed/37588590 http://dx.doi.org/10.3389/fimmu.2023.1225178 Text en Copyright © 2023 Wu, Singla, Liu and Hong https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Wu, Xin Singla, Sidhant Liu, Jianhua J. Hong, Liang The role of macrophage ion channels in the progression of atherosclerosis |
title | The role of macrophage ion channels in the progression of atherosclerosis |
title_full | The role of macrophage ion channels in the progression of atherosclerosis |
title_fullStr | The role of macrophage ion channels in the progression of atherosclerosis |
title_full_unstemmed | The role of macrophage ion channels in the progression of atherosclerosis |
title_short | The role of macrophage ion channels in the progression of atherosclerosis |
title_sort | role of macrophage ion channels in the progression of atherosclerosis |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425548/ https://www.ncbi.nlm.nih.gov/pubmed/37588590 http://dx.doi.org/10.3389/fimmu.2023.1225178 |
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