Human granzyme B regulatory B cells prevent effector CD4+CD25- T cell proliferation through a mechanism dependent from lymphotoxin alpha

INTRODUCTION: Human Granzyme B (GZMB) regulatory B cells (Bregs) have suppressive properties on CD4+ effector T cells by a mechanism partially dependent on GZMB. Moreover, these cells may be easily induced in vitro making them interesting for cell therapy. METHODS: We characterized this population o...

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Detalles Bibliográficos
Autores principales: Sailliet, Nicolas, Mai, Hoa-Le, Dupuy, Amandine, Tilly, Gaëlle, Fourgeux, Cynthia, Braud, Martin, Giral, Magali, Robert, Jean-Michel, Degauque, Nicolas, Danger, Richard, Poschmann, Jeremie, Brouard, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425555/
https://www.ncbi.nlm.nih.gov/pubmed/37588598
http://dx.doi.org/10.3389/fimmu.2023.1183714

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