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Factors influencing the prognosis patients with Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma undergoing salvage surgery after conversion therapy

BACKGROUND: The aim of this study was to investigate the prognostic factors influencing the outcome of patients with Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma (HCC) receiving salvage surgery after conversion therapy based on tyrosine kinase inhibitors (TKIs) and anti-programmed...

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Autores principales: Pan, Yingwei, Yang, Li, Cao, Yinbiao, Jun, Han, Tang, Haowen, Zhang, Wenwen, Wan, Tao, Jiao, Tianyu, Hu, Bingyang, Lu, Shichun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425648/
https://www.ncbi.nlm.nih.gov/pubmed/37588743
http://dx.doi.org/10.21037/tcr-23-70
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author Pan, Yingwei
Yang, Li
Cao, Yinbiao
Jun, Han
Tang, Haowen
Zhang, Wenwen
Wan, Tao
Jiao, Tianyu
Hu, Bingyang
Lu, Shichun
author_facet Pan, Yingwei
Yang, Li
Cao, Yinbiao
Jun, Han
Tang, Haowen
Zhang, Wenwen
Wan, Tao
Jiao, Tianyu
Hu, Bingyang
Lu, Shichun
author_sort Pan, Yingwei
collection PubMed
description BACKGROUND: The aim of this study was to investigate the prognostic factors influencing the outcome of patients with Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma (HCC) receiving salvage surgery after conversion therapy based on tyrosine kinase inhibitors (TKIs) and anti-programmed death-1 (PD-1) antibodies. METHODS: From June 2018 to December 2022, patients receiving salvage surgery after conversion therapy based on PD-1 and TKIs at the Faculty of Hepato-Pancreato-Biliary Surgery, Chinese PLA General Hospital were retrospectively recruited for this study. Overall survival (OS) and recurrence-free survival (RFS) were observed as the primary end point in the Cox analysis of prognostic factors among this study. RESULTS: The 6- and 12-month RFS rates were 77.0% and 64.8%, respectively, while the 6-, 12-, 24-, and 36-month OS rates were 98.4%, 93.4%, 76.8%, and 69.8%, respectively. The median OS and RFS were not reached. On multivariable Cox regression analyses, low serum alpha fetoprotein (AFP) level (≤20 ng/mL) after conversion therapy [hazard ratio (HR) 0.186, 95% CI: 0.039–0.887; P=0.035) and microvascular invasion (MVI) grade II (HR 3.054, 95% CI: 1.000–9.329; P=0.050) were independent factors associated with a higher OS and RFS. CONCLUSIONS: For patients with Barcelona Clinic Liver Cancer stage C (BCLC-C) HCC, lower AFP level after conversion therapy (<20 ng/mL) and MVI II were associated with a higher OS and lower RFS rate, respectively.
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spelling pubmed-104256482023-08-16 Factors influencing the prognosis patients with Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma undergoing salvage surgery after conversion therapy Pan, Yingwei Yang, Li Cao, Yinbiao Jun, Han Tang, Haowen Zhang, Wenwen Wan, Tao Jiao, Tianyu Hu, Bingyang Lu, Shichun Transl Cancer Res Original Article BACKGROUND: The aim of this study was to investigate the prognostic factors influencing the outcome of patients with Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma (HCC) receiving salvage surgery after conversion therapy based on tyrosine kinase inhibitors (TKIs) and anti-programmed death-1 (PD-1) antibodies. METHODS: From June 2018 to December 2022, patients receiving salvage surgery after conversion therapy based on PD-1 and TKIs at the Faculty of Hepato-Pancreato-Biliary Surgery, Chinese PLA General Hospital were retrospectively recruited for this study. Overall survival (OS) and recurrence-free survival (RFS) were observed as the primary end point in the Cox analysis of prognostic factors among this study. RESULTS: The 6- and 12-month RFS rates were 77.0% and 64.8%, respectively, while the 6-, 12-, 24-, and 36-month OS rates were 98.4%, 93.4%, 76.8%, and 69.8%, respectively. The median OS and RFS were not reached. On multivariable Cox regression analyses, low serum alpha fetoprotein (AFP) level (≤20 ng/mL) after conversion therapy [hazard ratio (HR) 0.186, 95% CI: 0.039–0.887; P=0.035) and microvascular invasion (MVI) grade II (HR 3.054, 95% CI: 1.000–9.329; P=0.050) were independent factors associated with a higher OS and RFS. CONCLUSIONS: For patients with Barcelona Clinic Liver Cancer stage C (BCLC-C) HCC, lower AFP level after conversion therapy (<20 ng/mL) and MVI II were associated with a higher OS and lower RFS rate, respectively. AME Publishing Company 2023-06-13 2023-07-31 /pmc/articles/PMC10425648/ /pubmed/37588743 http://dx.doi.org/10.21037/tcr-23-70 Text en 2023 Translational Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Pan, Yingwei
Yang, Li
Cao, Yinbiao
Jun, Han
Tang, Haowen
Zhang, Wenwen
Wan, Tao
Jiao, Tianyu
Hu, Bingyang
Lu, Shichun
Factors influencing the prognosis patients with Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma undergoing salvage surgery after conversion therapy
title Factors influencing the prognosis patients with Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma undergoing salvage surgery after conversion therapy
title_full Factors influencing the prognosis patients with Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma undergoing salvage surgery after conversion therapy
title_fullStr Factors influencing the prognosis patients with Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma undergoing salvage surgery after conversion therapy
title_full_unstemmed Factors influencing the prognosis patients with Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma undergoing salvage surgery after conversion therapy
title_short Factors influencing the prognosis patients with Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma undergoing salvage surgery after conversion therapy
title_sort factors influencing the prognosis patients with barcelona clinic liver cancer stage c hepatocellular carcinoma undergoing salvage surgery after conversion therapy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425648/
https://www.ncbi.nlm.nih.gov/pubmed/37588743
http://dx.doi.org/10.21037/tcr-23-70
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