Dual Targeting of Apoptotic and Signaling Pathways in T-Lineage Acute Lymphoblastic Leukemia

PURPOSE: Relapsed T-acute lymphoblastic leukemia (T-ALL) has limited treatment options. We investigated mechanisms of resistance to BH3 mimetics in T-ALL to develop rational combination strategies. We also looked at the preclinical efficacy of NWP-0476, a novel BCL-2/BCL-xL inhibitor, as single agen...

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Detalles Bibliográficos
Autores principales: Saygin, Caner, Giordano, Giorgia, Shimamoto, Kathryn, Eisfelder, Bart, Thomas-Toth, Anika, Venkataraman, Girish, Ananthanarayanan, Vijayalakshmi, Vincent, Tiffaney L., DuVall, Adam, Patel, Anand A., Chen, Yi, Tan, Fenlai, Anthony, Stephen P., Chen, Yu, Shen, Yue, Odenike, Olatoyosi, Teachey, David T., Kee, Barbara L., LaBelle, James, Stock, Wendy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425730/
https://www.ncbi.nlm.nih.gov/pubmed/37363966
http://dx.doi.org/10.1158/1078-0432.CCR-23-0415

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