Discovery and Targeting of a Noncanonical Mechanism of Sarcoma Resistance to ADI-PEG20 Mediated by the Microenvironment

PURPOSE: Many cancers lack argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme of arginine biosynthesis. This deficiency causes arginine auxotrophy, targetable by extracellular arginine-degrading enzymes such as ADI-PEG20. Long-term tumor resistance has thus far been attributed solely to...

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Detalles Bibliográficos
Autores principales: Rogers, Leonard C., Kremer, Jeff C., Brashears, Caitlyn B., Lin, Zongtao, Hu, Zhixian, Bastos, Alliny C.S., Baker, Adriana, Fettig, Nicole, Zhou, Dong, Shoghi, Kooresh I., Dehner, Carina A., Chrisinger, John S.A., Bomalaski, John S., Garcia, Benjamin A., Oyama, Toshinao, White, Eileen P., Van Tine, Brian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425734/
https://www.ncbi.nlm.nih.gov/pubmed/37339179
http://dx.doi.org/10.1158/1078-0432.CCR-22-2642

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