Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia

CDC42 controls intestinal epithelial (IEC) stem cell (IESC) division. How aberrant CDC42 initiates intestinal inflammation or neoplasia is unclear. We utilized models of inflammatory bowel diseases (IBD), colorectal cancer, aging, and IESC injury to determine the loss of intestinal Cdc42 upon inflam...

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Detalles Bibliográficos
Autores principales: Zhang, Dongsheng, Tang, Wenjuan, Niu, Haitao, Tse, William, Ruan, Hai-Bin, Dolznig, Helmut, Knösel, Thomas, Karl-Heinz, Friedrich, Themanns, Madeleine, Wang, Jiang, Song, Mingquan, Denson, Lee, Kenner, Lukas, Moriggl, Richard, Zheng, Yi, Han, Xiaonan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2023
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425749/
https://www.ncbi.nlm.nih.gov/pubmed/37588188
http://dx.doi.org/10.1016/j.gendis.2022.11.024

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