Overcoming adaptive resistance in AML by synergistically targeting FOXO3A-GNG7-mTOR axis with FOXO3A inhibitor Gardenoside and rapamycin

Therapeutic targeting FOXO3A (a forkhead transcription factor) represents a promising strategy to suppress acute myeloid leukemia (AML). However, the effective inhibitors that target FOXO3A are lacking and the adaptive response signaling weakens the cytotoxic effect of FOXO3A depletion on AML cells....

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Detalles Bibliográficos
Autores principales: Chen, Zhe, Guo, Qian, Huang, Shichen, Li, Lei, Wu, Feng, Liu, Zhilong, Li, Zhigang, Chen, Tao, Song, Guanbin, Xu, Shuangnian, Chen, Jieping, Hou, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2023
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425752/
https://www.ncbi.nlm.nih.gov/pubmed/37588187
http://dx.doi.org/10.1016/j.gendis.2023.01.002

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