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Cryo‐EM structure of the chain‐elongating E3 ubiquitin ligase UBR5

UBR5 is a nuclear E3 ligase that ubiquitinates a vast range of substrates for proteasomal degradation. This HECT domain‐containing ubiquitin ligase has recently been identified as an important regulator of oncogenes, e.g., MYC, but little is known about its structure or mechanisms of substrate engag...

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Detalles Bibliográficos
Autores principales:	Hodáková, Zuzana, Grishkovskaya, Irina, Brunner, Hanna L, Bolhuis, Derek L, Belačić, Katarina, Schleiffer, Alexander, Kotisch, Harald, Brown, Nicholas G, Haselbach, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425842/ https://www.ncbi.nlm.nih.gov/pubmed/37409633 http://dx.doi.org/10.15252/embj.2022113348

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