Cargando…

Mesenchymal stem cell engineering by ARCA analog-capped mRNA

We previously have shown that mRNA-based engineering may enhance mesenchymal stem cell (MSC) trafficking. However, optimal conditions for in vitro mRNA engineering of MSCs are unknown. Here, we investigated several independent variables: (1) transfection factor (Lipofectamine 2000 vs. TransIT), (2)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Andrzejewska, Anna, Grzela, Renata, Stankiewicz-Drogon, Anna, Rogujski, Piotr, Nagaraj, Siranjeevi, Darzynkiewicz, Edward, Lukomska, Barbara, Janowski, Miroslaw
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425852/ https://www.ncbi.nlm.nih.gov/pubmed/37588684 http://dx.doi.org/10.1016/j.omtn.2023.07.006

Ejemplares similares

RNA sensor response in HeLa cells for transfected mRNAs prepared in vitro by SP6 and HiT7 RNA polymerases: A comparative study
por: Nagaraj, Siranjeevi, et al.
Publicado: (2022)

N2 modified dinucleotide cap analogs as a potent tool for mRNA engineering
por: Grzela, Renata, et al.
Publicado: (2023)

Mesenchymal Stem Cells for Neurological Disorders
por: Andrzejewska, Anna, et al.
Publicado: (2021)

Neuroinflammation as a target for treatment of stroke using mesenchymal stem cells and extracellular vesicles
por: Dabrowska, Sylwia, et al.
Publicado: (2019)

Immunomodulatory and Regenerative Effects of Mesenchymal Stem Cells and Extracellular Vesicles: Therapeutic Outlook for Inflammatory and Degenerative Diseases
por: Dabrowska, Sylwia, et al.
Publicado: (2021)

The legacy of mRNA engineering: A lineup of pioneers for the Nobel Prize
por: Janowski, Miroslaw, et al.
Publicado: (2022)

Hydrolytic activity of human Nudt16 enzyme on dinucleotide cap analogs and short capped oligonucleotides
por: Grzela, Renata, et al.
Publicado: (2018)

Mesenchymal stem cells injected into carotid artery to target focal brain injury home to perivascular space
por: Andrzejewska, Anna, et al.
Publicado: (2020)

Labeling of human mesenchymal stem cells with different classes of vital stains: robustness and toxicity
por: Andrzejewska, Anna, et al.
Publicado: (2019)

CAP-MAP: cap analysis protocol with minimal analyte processing, a rapid and sensitive approach to analysing mRNA cap structures
por: Galloway, Alison, et al.
Publicado: (2020)

Translation, but not transfection limits clinically relevant, exogenous mRNA based induction of alpha-4 integrin expression on human mesenchymal stem cells
por: Nowakowski, Adam, et al.
Publicado: (2017)

Cap analogs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential
por: Strenkowska, Malwina, et al.
Publicado: (2016)

Human bone marrow mesenchymal stem cell-derived extracellular vesicles attenuate neuroinflammation evoked by focal brain injury in rats
por: Dabrowska, Sylwia, et al.
Publicado: (2019)

Extracellular Vesicles in Physiology, Pathology, and Therapy of the Immune and Central Nervous System, with Focus on Extracellular Vesicles Derived from Mesenchymal Stem Cells as Therapeutic Tools
por: Koniusz, Sylwia, et al.
Publicado: (2016)

Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and Survival
por: Nowakowski, Adam, et al.
Publicado: (2016)

Transplantation of Human Glial Progenitors to Immunodeficient Neonatal Mice with Amyotrophic Lateral Sclerosis (SOD1/rag2)
por: Stanaszek, Luiza, et al.
Publicado: (2022)

Triazole-containing monophosphate mRNA cap analogs as effective translation inhibitors
por: Piecyk, Karolina, et al.
Publicado: (2014)

Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes
por: Kowalska, Joanna, et al.
Publicado: (2014)

Pre- and postmortem imaging of transplanted cells
por: Andrzejewska, Anna, et al.
Publicado: (2015)

SOD1/Rag2 Mice with Low Copy Number of SOD1 Gene as a New Long-Living Immunodeficient Model of ALS
por: Majchrzak, M., et al.
Publicado: (2019)

The cerebral embolism evoked by intra-arterial delivery of allogeneic bone marrow mesenchymal stem cells in rats is related to cell dose and infusion velocity
por: Cui, Li-li, et al.
Publicado: (2015)

N2 modified cap analogues as translation inhibitors and substrates for preparation of therapeutic mRNA
por: Kurpiejewski, Karol, et al.
Publicado: (2023)

Kinetic analysis of IFIT1 and IFIT5 interactions with different native and engineered RNAs and its consequences for designing mRNA-based therapeutics
por: Miedziak, Beata, et al.
Publicado: (2020)

Myelin-Independent Therapeutic Potential of Canine Glial-Restricted Progenitors Transplanted in Mouse Model of Dysmyelinating Disease
por: Stanaszek, Luiza, et al.
Publicado: (2021)

N1-Propargylguanosine Modified mRNA Cap Analogs: Synthesis, Reactivity, and Applications to the Study of Cap-Binding Proteins
por: Kopcial, Michal, et al.
Publicado: (2019)

El arca sobrecargada
por: Durrell, Gerald, 1925-1995
Publicado: (1995)

El arca inmovil /
por: Durrell, Gerald Malcolm, 1925-
Publicado: (1984)

Effect of the His-Tag Location on Decapping Scavenger Enzymes and Their Hydrolytic Activity toward Cap Analogs
por: Ferenc-Mrozek, Aleksandra, et al.
Publicado: (2020)

Structural analysis of human 2′-O-ribose methyltransferases involved in mRNA cap structure formation
por: Smietanski, Miroslaw, et al.
Publicado: (2014)

A methylcellulose/agarose hydrogel as an innovative scaffold for tissue engineering
por: Niemczyk-Soczynska, Beata, et al.
Publicado: (2022)

Arca de Noé : clase turista
por: Kishon, Ephraim
Publicado: (1964)

El arca de Noé
por: Carballido, Emilio
Publicado: (1989)

El arca de noé
por: Rops-Daniel
Publicado: (1963)

El arca de Noé /
por: Carballido, Emilio
Publicado: (1994)

El arca de colores : novelas
por: María Enriqueta, 1872-1968
Publicado: (1929)

Cap analogs with a hydrophobic photocleavable tag enable facile purification of fully capped mRNA with various cap structures
por: Inagaki, Masahito, et al.
Publicado: (2023)

Arca de Guadalupe : cinco siglos de inspiración
Publicado: (2007)

Arca de musica : instrumental music in new Spain.
Publicado: (2017)

Manganese-Labeled Alginate Hydrogels for Image-Guided Cell Transplantation
por: Araszkiewicz, Antonina M., et al.
Publicado: (2022)

Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation
por: Galloway, Alison, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_l6e4hkium2m7bls19eu9ivhg2l