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Mitochondria-related signaling pathways involved in breast cancer regulate ferroptosis
Ferroptosis is a novel form of regulated cell death characterized by iron-dependent excessive lipid peroxidation. The core organelle involved in ferroptosis is mitochondria. Mitochondria undergoing ferroptosis are distinct from normal mitochondria in terms of morphology, biochemistry, gene expressio...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chongqing Medical University
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425853/ https://www.ncbi.nlm.nih.gov/pubmed/37588231 http://dx.doi.org/10.1016/j.gendis.2023.03.019 |
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author | Dong, Xinrui Li, Ye Sheng, Xiaonan Zhou, Weihang Sun, Aijun Dai, Huijuan |
author_facet | Dong, Xinrui Li, Ye Sheng, Xiaonan Zhou, Weihang Sun, Aijun Dai, Huijuan |
author_sort | Dong, Xinrui |
collection | PubMed |
description | Ferroptosis is a novel form of regulated cell death characterized by iron-dependent excessive lipid peroxidation. The core organelle involved in ferroptosis is mitochondria. Mitochondria undergoing ferroptosis are distinct from normal mitochondria in terms of morphology, biochemistry, gene expression, and energy metabolism. An increasing number of studies have shown that mitochondria and their associated metabolic pathways mediate ferroptosis in the development and progression of breast cancer. In this review, we discuss the relevant research about ferroptosis in breast cancer and provide a comprehensive summary of mitochondrial regulation in ferroptosis from the perspective of lipid metabolism, oxidative phosphorylation, ion metabolism, glycometabolism, and nucleotide metabolism. We also summarize the application of mitochondrial metabolism-related pathways as ferroptosis treatment targets. Here we provide new insights into the relationship between mitochondria, ferroptosis, and breast cancer treatment. |
format | Online Article Text |
id | pubmed-10425853 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Chongqing Medical University |
record_format | MEDLINE/PubMed |
spelling | pubmed-104258532023-08-16 Mitochondria-related signaling pathways involved in breast cancer regulate ferroptosis Dong, Xinrui Li, Ye Sheng, Xiaonan Zhou, Weihang Sun, Aijun Dai, Huijuan Genes Dis Review Article Ferroptosis is a novel form of regulated cell death characterized by iron-dependent excessive lipid peroxidation. The core organelle involved in ferroptosis is mitochondria. Mitochondria undergoing ferroptosis are distinct from normal mitochondria in terms of morphology, biochemistry, gene expression, and energy metabolism. An increasing number of studies have shown that mitochondria and their associated metabolic pathways mediate ferroptosis in the development and progression of breast cancer. In this review, we discuss the relevant research about ferroptosis in breast cancer and provide a comprehensive summary of mitochondrial regulation in ferroptosis from the perspective of lipid metabolism, oxidative phosphorylation, ion metabolism, glycometabolism, and nucleotide metabolism. We also summarize the application of mitochondrial metabolism-related pathways as ferroptosis treatment targets. Here we provide new insights into the relationship between mitochondria, ferroptosis, and breast cancer treatment. Chongqing Medical University 2023-04-25 /pmc/articles/PMC10425853/ /pubmed/37588231 http://dx.doi.org/10.1016/j.gendis.2023.03.019 Text en © 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Dong, Xinrui Li, Ye Sheng, Xiaonan Zhou, Weihang Sun, Aijun Dai, Huijuan Mitochondria-related signaling pathways involved in breast cancer regulate ferroptosis |
title | Mitochondria-related signaling pathways involved in breast cancer regulate ferroptosis |
title_full | Mitochondria-related signaling pathways involved in breast cancer regulate ferroptosis |
title_fullStr | Mitochondria-related signaling pathways involved in breast cancer regulate ferroptosis |
title_full_unstemmed | Mitochondria-related signaling pathways involved in breast cancer regulate ferroptosis |
title_short | Mitochondria-related signaling pathways involved in breast cancer regulate ferroptosis |
title_sort | mitochondria-related signaling pathways involved in breast cancer regulate ferroptosis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425853/ https://www.ncbi.nlm.nih.gov/pubmed/37588231 http://dx.doi.org/10.1016/j.gendis.2023.03.019 |
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