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IL-27 mediates immune response of pneumococcal vaccine SPY1 through Th17 and memory CD4(+)T cells

Vaccination is an effective means of preventing pneumococcal disease and SPY1 is a live attenuated pneumococcal vaccine we obtained earlier. We found IL-27 and its specific receptor (WSX-1) were increased in SPY1 vaccinated mice. Bacterial clearance and survival rates were decreased in SPY1 vaccinat...

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Detalles Bibliográficos
Autores principales:	Zhang, Yanyu, Gao, Song, Yao, Shifei, Weng, Danlin, Wang, Yan, Huang, Qi, Zhang, Xuemei, Wang, Hong, Xu, Wenchun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425906/ https://www.ncbi.nlm.nih.gov/pubmed/37588169 http://dx.doi.org/10.1016/j.isci.2023.107464

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