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Creatine energy substrate increases bone density in the Pah(enu2) classical PKU mouse in the context of phenylalanine restriction

Pathophysiology of osteopenia in phenylalanine hydroxylase (PAH) deficient phenylketonuria (PKU) is poorly characterized. The Pah(enu2) mouse is universally osteopenic where dietary phenylalanine (Phe) management with amino acid defined chow does not improve bone density. We previously demonstrated...

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Detalles Bibliográficos
Autores principales:	Dobrowolski, Steven F., Tourkova, Irina L., Larrouture, Quitterie C., Blair, Harry C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425935/ https://www.ncbi.nlm.nih.gov/pubmed/37588420 http://dx.doi.org/10.1016/j.ymgmr.2023.100996

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