Autophagy ablation in skeletal muscles worsens sepsis-induced muscle wasting, impairs whole-body metabolism, and decreases survival

Septic patients frequently develop skeletal muscle wasting and weakness, resulting in severe clinical consequences and adverse outcomes. Sepsis triggers sustained induction of autophagy, a key cellular degradative pathway, in skeletal muscles. However, the impact of enhanced autophagy on sepsis-indu...

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Detalles Bibliográficos
Autores principales: Leduc-Gaudet, Jean-Philippe, Miguez, Kayla, Cefis, Marina, Faitg, Julie, Moamer, Alaa, Chaffer, Tomer Jordi, Reynaud, Olivier, Broering, Felipe E., Shams, Anwar, Mayaki, Dominique, Huck, Laurent, Sandri, Marco, Gouspillou, Gilles, Hussain, Sabah N.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10425945/
https://www.ncbi.nlm.nih.gov/pubmed/37588163
http://dx.doi.org/10.1016/j.isci.2023.107475

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