Epigenetic instability caused by absence of CIZ1 drives transformation during quiescence cycles

BACKGROUND: Cip1-interacting zinc finger protein 1 (CIZ1) forms RNA-dependent protein assemblies that stabilise epigenetic state, notable at the inactive X chromosome in females. CIZ1 has been linked with a range of human cancers and in mice genetic deletion of CIZ1 manifests as hyperproliferative l...

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Detalles Bibliográficos
Autores principales: Dobbs, Olivia G., Wilson, Rosemary H. C., Newling, Katherine, Ainscough, Justin F.-X., Coverley, Dawn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426085/
https://www.ncbi.nlm.nih.gov/pubmed/37580709
http://dx.doi.org/10.1186/s12915-023-01671-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426085/
https://www.ncbi.nlm.nih.gov/pubmed/37580709
http://dx.doi.org/10.1186/s12915-023-01671-6

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