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Unleashing T cell anti-tumor immunity: new potential for 5-Nonloxytryptamine as an agent mediating MHC-I upregulation in tumors
BACKGROUND: New therapies are urgently needed in melanoma, particularly in late-stage patients not responsive to immunotherapies and kinase inhibitors. To uncover novel potentiators of T cell anti-tumor immunity, we carried out an ex vivo pharmacological screen and identified 5-Nonyloxytryptamine (5...
Autores principales: | Stachura, Paweł, Liu, Wei, Xu, Haifeng C., Wlodarczyk, Agnès, Stencel, Olivia, Pandey, Piyush, Vogt, Melina, Bhatia, Sanil, Picard, Daniel, Remke, Marc, Lang, Karl S., Häussinger, Dieter, Homey, Bernhard, Lang, Philipp A., Borkhardt, Arndt, Pandyra, Aleksandra A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426104/ https://www.ncbi.nlm.nih.gov/pubmed/37582744 http://dx.doi.org/10.1186/s12943-023-01833-8 |
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