Cathepsin B abundance, activity and microglial localisation in Alzheimer’s disease-Down syndrome and early onset Alzheimer’s disease; the role of elevated cystatin B

Cathepsin B is a cysteine protease that is implicated in multiple aspects of Alzheimer’s disease pathogenesis. The endogenous inhibitor of this enzyme, cystatin B (CSTB) is encoded on chromosome 21. Thus, individuals who have Down syndrome, a genetic condition caused by having an additional copy of...

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Detalles Bibliográficos
Autores principales: Wu, Yixing, Mumford, Paige, Noy, Suzanna, Cleverley, Karen, Mrzyglod, Alicja, Luo, Dinghao, van Dalen, Floris, Verdoes, Martijn, Fisher, Elizabeth M. C., Wiseman, Frances K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426223/
https://www.ncbi.nlm.nih.gov/pubmed/37580797
http://dx.doi.org/10.1186/s40478-023-01632-8

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