Cargando…
Technological advances in fibrin for tissue engineering
Fibrin is a promising natural polymer that is widely used for diverse applications, such as hemostatic glue, carrier for drug and cell delivery, and matrix for tissue engineering. Despite the significant advances in the use of fibrin for bioengineering and biomedical applications, some of its charac...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426312/ https://www.ncbi.nlm.nih.gov/pubmed/37588339 http://dx.doi.org/10.1177/20417314231190288 |
_version_ | 1785090030386020352 |
---|---|
author | Sanz-Horta, Raúl Matesanz, Ana Gallardo, Alberto Reinecke, Helmut Jorcano, José Luis Acedo, Pablo Velasco, Diego Elvira, Carlos |
author_facet | Sanz-Horta, Raúl Matesanz, Ana Gallardo, Alberto Reinecke, Helmut Jorcano, José Luis Acedo, Pablo Velasco, Diego Elvira, Carlos |
author_sort | Sanz-Horta, Raúl |
collection | PubMed |
description | Fibrin is a promising natural polymer that is widely used for diverse applications, such as hemostatic glue, carrier for drug and cell delivery, and matrix for tissue engineering. Despite the significant advances in the use of fibrin for bioengineering and biomedical applications, some of its characteristics must be improved for suitability for general use. For example, fibrin hydrogels tend to shrink and degrade quickly after polymerization, particularly when they contain embedded cells. In addition, their poor mechanical properties and batch-to-batch variability affect their handling, long-term stability, standardization, and reliability. One of the most widely used approaches to improve their properties has been modification of the structure and composition of fibrin hydrogels. In this review, recent advances in composite fibrin scaffolds, chemically modified fibrin hydrogels, interpenetrated polymer network (IPN) hydrogels composed of fibrin and other synthetic or natural polymers are critically reviewed, focusing on their use for tissue engineering. |
format | Online Article Text |
id | pubmed-10426312 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-104263122023-08-16 Technological advances in fibrin for tissue engineering Sanz-Horta, Raúl Matesanz, Ana Gallardo, Alberto Reinecke, Helmut Jorcano, José Luis Acedo, Pablo Velasco, Diego Elvira, Carlos J Tissue Eng Review Fibrin is a promising natural polymer that is widely used for diverse applications, such as hemostatic glue, carrier for drug and cell delivery, and matrix for tissue engineering. Despite the significant advances in the use of fibrin for bioengineering and biomedical applications, some of its characteristics must be improved for suitability for general use. For example, fibrin hydrogels tend to shrink and degrade quickly after polymerization, particularly when they contain embedded cells. In addition, their poor mechanical properties and batch-to-batch variability affect their handling, long-term stability, standardization, and reliability. One of the most widely used approaches to improve their properties has been modification of the structure and composition of fibrin hydrogels. In this review, recent advances in composite fibrin scaffolds, chemically modified fibrin hydrogels, interpenetrated polymer network (IPN) hydrogels composed of fibrin and other synthetic or natural polymers are critically reviewed, focusing on their use for tissue engineering. SAGE Publications 2023-08-14 /pmc/articles/PMC10426312/ /pubmed/37588339 http://dx.doi.org/10.1177/20417314231190288 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Sanz-Horta, Raúl Matesanz, Ana Gallardo, Alberto Reinecke, Helmut Jorcano, José Luis Acedo, Pablo Velasco, Diego Elvira, Carlos Technological advances in fibrin for tissue engineering |
title | Technological advances in fibrin for tissue engineering |
title_full | Technological advances in fibrin for tissue engineering |
title_fullStr | Technological advances in fibrin for tissue engineering |
title_full_unstemmed | Technological advances in fibrin for tissue engineering |
title_short | Technological advances in fibrin for tissue engineering |
title_sort | technological advances in fibrin for tissue engineering |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426312/ https://www.ncbi.nlm.nih.gov/pubmed/37588339 http://dx.doi.org/10.1177/20417314231190288 |
work_keys_str_mv | AT sanzhortaraul technologicaladvancesinfibrinfortissueengineering AT matesanzana technologicaladvancesinfibrinfortissueengineering AT gallardoalberto technologicaladvancesinfibrinfortissueengineering AT reineckehelmut technologicaladvancesinfibrinfortissueengineering AT jorcanojoseluis technologicaladvancesinfibrinfortissueengineering AT acedopablo technologicaladvancesinfibrinfortissueengineering AT velascodiego technologicaladvancesinfibrinfortissueengineering AT elviracarlos technologicaladvancesinfibrinfortissueengineering |