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Technological advances in fibrin for tissue engineering

Fibrin is a promising natural polymer that is widely used for diverse applications, such as hemostatic glue, carrier for drug and cell delivery, and matrix for tissue engineering. Despite the significant advances in the use of fibrin for bioengineering and biomedical applications, some of its charac...

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Autores principales: Sanz-Horta, Raúl, Matesanz, Ana, Gallardo, Alberto, Reinecke, Helmut, Jorcano, José Luis, Acedo, Pablo, Velasco, Diego, Elvira, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426312/
https://www.ncbi.nlm.nih.gov/pubmed/37588339
http://dx.doi.org/10.1177/20417314231190288
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author Sanz-Horta, Raúl
Matesanz, Ana
Gallardo, Alberto
Reinecke, Helmut
Jorcano, José Luis
Acedo, Pablo
Velasco, Diego
Elvira, Carlos
author_facet Sanz-Horta, Raúl
Matesanz, Ana
Gallardo, Alberto
Reinecke, Helmut
Jorcano, José Luis
Acedo, Pablo
Velasco, Diego
Elvira, Carlos
author_sort Sanz-Horta, Raúl
collection PubMed
description Fibrin is a promising natural polymer that is widely used for diverse applications, such as hemostatic glue, carrier for drug and cell delivery, and matrix for tissue engineering. Despite the significant advances in the use of fibrin for bioengineering and biomedical applications, some of its characteristics must be improved for suitability for general use. For example, fibrin hydrogels tend to shrink and degrade quickly after polymerization, particularly when they contain embedded cells. In addition, their poor mechanical properties and batch-to-batch variability affect their handling, long-term stability, standardization, and reliability. One of the most widely used approaches to improve their properties has been modification of the structure and composition of fibrin hydrogels. In this review, recent advances in composite fibrin scaffolds, chemically modified fibrin hydrogels, interpenetrated polymer network (IPN) hydrogels composed of fibrin and other synthetic or natural polymers are critically reviewed, focusing on their use for tissue engineering.
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spelling pubmed-104263122023-08-16 Technological advances in fibrin for tissue engineering Sanz-Horta, Raúl Matesanz, Ana Gallardo, Alberto Reinecke, Helmut Jorcano, José Luis Acedo, Pablo Velasco, Diego Elvira, Carlos J Tissue Eng Review Fibrin is a promising natural polymer that is widely used for diverse applications, such as hemostatic glue, carrier for drug and cell delivery, and matrix for tissue engineering. Despite the significant advances in the use of fibrin for bioengineering and biomedical applications, some of its characteristics must be improved for suitability for general use. For example, fibrin hydrogels tend to shrink and degrade quickly after polymerization, particularly when they contain embedded cells. In addition, their poor mechanical properties and batch-to-batch variability affect their handling, long-term stability, standardization, and reliability. One of the most widely used approaches to improve their properties has been modification of the structure and composition of fibrin hydrogels. In this review, recent advances in composite fibrin scaffolds, chemically modified fibrin hydrogels, interpenetrated polymer network (IPN) hydrogels composed of fibrin and other synthetic or natural polymers are critically reviewed, focusing on their use for tissue engineering. SAGE Publications 2023-08-14 /pmc/articles/PMC10426312/ /pubmed/37588339 http://dx.doi.org/10.1177/20417314231190288 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Sanz-Horta, Raúl
Matesanz, Ana
Gallardo, Alberto
Reinecke, Helmut
Jorcano, José Luis
Acedo, Pablo
Velasco, Diego
Elvira, Carlos
Technological advances in fibrin for tissue engineering
title Technological advances in fibrin for tissue engineering
title_full Technological advances in fibrin for tissue engineering
title_fullStr Technological advances in fibrin for tissue engineering
title_full_unstemmed Technological advances in fibrin for tissue engineering
title_short Technological advances in fibrin for tissue engineering
title_sort technological advances in fibrin for tissue engineering
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426312/
https://www.ncbi.nlm.nih.gov/pubmed/37588339
http://dx.doi.org/10.1177/20417314231190288
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