Cargando…

Outreach, Screening, and Randomization of APOE ε4 Carriers into an Alzheimer’s Prevention Trial: A global Perspective from the API Generation Program

BACKGROUND: Alzheimer’s disease (AD) prevention trials require a large outreach and screening funnel to identify cognitively unimpaired adults who meet the study’s inclusion criteria, such as certain clinical or demographic criteria, genetic risk factors, and/or biomarker evidence of the disease. OB...

Descripción completa

Detalles Bibliográficos
Autores principales:	Walsh, T., Duff, L., Riviere, M.-E., Tariot, P.N., Doak, K., Smith, M., Borowsky, B., Lopez, C. Lopez, Arratia, P.C., Liu, F., Scholten, I., Gordon, D., Arbuckle, J., Graf, A., Quinn, M., Ricart, J., Langbaum, J.B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426731/ https://www.ncbi.nlm.nih.gov/pubmed/37357285 http://dx.doi.org/10.14283/jpad.2023.27

Ejemplares similares

Alzheimer's Prevention Initiative Generation Program: Development of an APOE genetic counseling and disclosure process in the context of clinical trials
por: Langlois, Carolyn M., et al.
Publicado: (2019)

Association between an Alzheimer’s Disease-Related Index and APOE ε4 Gene Dose
por: Schraml, Frank, et al.
Publicado: (2013)

Rationale for the selection of dual primary endpoints in prevention studies of cognitively unimpaired individuals at genetic risk for developing symptoms of Alzheimer’s disease
por: Caputo, Angelika, et al.
Publicado: (2023)

Association of APOE Serum Levels and APOE ε2, ε3, and ε4 Alleles with Optic Neuritis
por: Momkute, Liucija, et al.
Publicado: (2022)

Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2 alleles
por: Walker, Rosie M., et al.
Publicado: (2021)

The Alzheimer’s Prevention Initiative Composite Cognitive Test: a practical measure for tracking cognitive decline in preclinical Alzheimer’s disease
por: Langbaum, Jessica B., et al.
Publicado: (2020)

Sex and APOE: A memory advantage in male APOE ε4 carriers in midlife
por: Zokaei, Nahid, et al.
Publicado: (2017)

APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts
por: Qian, Jing, et al.
Publicado: (2017)

APOEε4 and slow wave sleep in older adults
por: Tranah, Gregory J., et al.
Publicado: (2018)

Behavioral testing affects the phenotypic expression of APOE ε3 and APOE ε4 in targeted replacement mice and reduces the differences between them
por: Salomon-Zimri, Shiran, et al.
Publicado: (2015)

Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice
por: Pankiewicz, Joanna E, et al.
Publicado: (2014)

Peripheral apoE isoform levels in cognitively normal APOE ε3/ε4 individuals are associated with regional gray matter volume and cerebral glucose metabolism
por: Nielsen, Henrietta M., et al.
Publicado: (2017)

Differential associations of APOE-ε2 and APOE-ε4 alleles with PET-measured amyloid-β and tau deposition in older individuals without dementia
por: Salvadó, Gemma, et al.
Publicado: (2021)

Effects of age, amyloid, sex, and APOE ε4 on the CSF proteome in normal cognition
por: Wesenhagen, Kirsten E.J., et al.
Publicado: (2022)

Associations of the APOE ε2 and ε4 alleles and polygenic profiles comprising APOE-TOMM40-APOC1 variants with Alzheimer’s disease biomarkers
por: Kulminski, Alexander M., et al.
Publicado: (2022)

The Alzheimer's Prevention Initiative Generation Program: Study design of two randomized controlled trials for individuals at risk for clinical onset of Alzheimer's disease
por: Lopez Lopez, Cristina, et al.
Publicado: (2019)

Updated meta-analysis of the role of APOE ε2/ε3/ε4 alleles in frontotemporal lobar degeneration
por: Su, Wen-Hua, et al.
Publicado: (2017)

Symptomatic amyloid‐related imaging abnormalities in an APOE ε4/ε4 patient treated with aducanumab
por: VandeVrede, Lawren, et al.
Publicado: (2020)

Effect of APOE ε4 allele on survival and fertility in an adverse environment
por: van Exel, Eric, et al.
Publicado: (2017)

Anxiety correlates with cortical surface area in subjective cognitive decline: APOE ε4 carriers versus APOE ε4 non-carriers
por: Sun, Yu, et al.
Publicado: (2019)

Differences in resting-state brain networks and gray matter between APOE ε2 and APOE ε4 carriers in non-dementia elderly
por: Wang, Zhiyuan, et al.
Publicado: (2023)

Bioenergetic and inflammatory systemic phenotypes in Alzheimer’s disease APOE ε4‐carriers
por: Wilkins, Heather M., et al.
Publicado: (2021)

Age‐dependent effects of APOE ε4 in preclinical Alzheimer's disease
por: Bonham, Luke W., et al.
Publicado: (2016)

Is APOE ε4 associated with cognitive performance in early MS?
por: Engel, Sinah, et al.
Publicado: (2020)

The ε3 and ε4 Alleles of Human APOE Differentially Affect Tau Phosphorylation in Hyperinsulinemic and Pioglitazone Treated Mice
por: To, Alvina W. M., et al.
Publicado: (2011)

Brain imaging measurements of fibrillar amyloid‐β burden, paired helical filament tau burden, and atrophy in cognitively unimpaired persons with two, one, and no copies of the APOE ε4 allele
por: Ghisays, Valentina, et al.
Publicado: (2020)

Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome
por: Arnold, Matthias, et al.
Publicado: (2020)

APOE ε4 Is Associated with Disproportionate Progressive Hippocampal Atrophy in AD
por: Manning, Emily N., et al.
Publicado: (2014)

APOE ε2 is associated with increased tau pathology in primary tauopathy
por: Zhao, Na, et al.
Publicado: (2018)

The APOE(ε3/ε4) Genotype Drives Distinct Gene Signatures in the Cortex of Young Mice
por: Foley, Kate E., et al.
Publicado: (2022)

Association of APOE ε4/ε4 with fluid biomarkers in patients from the PUMCH dementia cohort
por: Shang, Li, et al.
Publicado: (2023)

THE RELATIONSHIP OF APOE ε4 TO THE RELATIVE TIMES AND HAZARDS OF DEMENTIA
por: Powell, Danielle, et al.
Publicado: (2019)

APOE ε4 and resting‐state functional connectivity in racially/ethnically diverse older adults
por: Turney, Indira C., et al.
Publicado: (2020)

Risk of dementia in APOE ε4 carriers is mitigated by a polygenic risk score
por: Ebenau, Jarith L., et al.
Publicado: (2021)

Behavioral and cognitive performance of humanized APOEε3/ε3 liver mice in relation to plasma apolipoprotein E levels
por: Kessler, Kat, et al.
Publicado: (2023)

ε2 allele and ε2-involved genotypes (ε2/ε2, ε2/ε3, and ε2/ε4) may confer the association of APOE genetic polymorphism with risks of nephropathy in type 2 diabetes: a meta-analysis
por: Shi, Jikang, et al.
Publicado: (2020)

APOE ε4, an Alzheimer’s disease susceptibility allele, and smoking cessation
por: Ashare, Rebecca L., et al.
Publicado: (2012)

APOEε4 and risk of Alzheimer’s disease – time to move forward
por: Lefterov, Iliya, et al.
Publicado: (2023)

Retinal imaging demonstrates reduced capillary density in clinically unimpaired APOE ε4 gene carriers
por: Elahi, Fanny M., et al.
Publicado: (2021)

Brain integrity is altered by hepatic APOE ε4 in humanized-liver mice
por: Giannisis, Andreas, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vse8crato09s44rb7b1m7g7hte