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Efficacy and safety of Danggui Niantong Decoction in patients with gout: a systematic review and meta-analysis
Background: This study aims to evaluate the efficacy and safety of Danggui Niantong Decoction (DGNT) systematically on gout treating. Methods: This study was registered in PROSPERO, and the registration number was CRD42021271607. By the end of December, 2022, literature research was conducted among...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426740/ https://www.ncbi.nlm.nih.gov/pubmed/37587984 http://dx.doi.org/10.3389/fphar.2023.1168863 |
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author | Peng, Sihan Tian, Jing Jin, Luchang Wang, Hongyan Xie, Chunguang Zheng, Jie Liu, Linfeng Cao, Jun Zhang, Wen Zhang, Xiangeng |
author_facet | Peng, Sihan Tian, Jing Jin, Luchang Wang, Hongyan Xie, Chunguang Zheng, Jie Liu, Linfeng Cao, Jun Zhang, Wen Zhang, Xiangeng |
author_sort | Peng, Sihan |
collection | PubMed |
description | Background: This study aims to evaluate the efficacy and safety of Danggui Niantong Decoction (DGNT) systematically on gout treating. Methods: This study was registered in PROSPERO, and the registration number was CRD42021271607. By the end of December, 2022, literature research was conducted among eight electronic databases. Main results of this study were blood uric acid (BUA) and Creactive protein (CRP). Secondary outcomes were erythrocyte sedimentation rate (ESR), serum creatinine (Scr), urinary protein quantified at 24 h (Upro), and interleukin-8 (IL-8). Study screening, data collection, as well as quality assessment were performed by two reviewers independently, and analysis was completed using Stata (SE15.0) and Review Manager (5.4). Results: A total number of 13 studies were included in our meta-analysis (n = 1,094 participants). Results showed DGNT combined with conventional western medicine (CWM) was more effective than WM alone in BUA (weighted mean differences (WMD) = −3.49, 95% confidence interval (CI) [−50.36, −32.59], p = 0.000), CRP (WMD = −41.48, 95% CI [−4.32, −2.66], p = 0.017), ESR (WMD = −6.23, 95% CI [−9.28, −3.17], p = 0.019), Scr (WMD = −18.64, 95% CI [−23.09, −14.19], p = 0.001), Upro (WMD = −0.72, 95% CI [−0.91, −0.53], p = 0.000), and IL-8 (WMD = −4.77, 95% CI [−11.48, 1.94], p = 0.000). None of the adverse effects noted were severe, and no life-threatening event was reported. Conclusion: This study shows that DGNT combined with CWM seems to have an effective clinical therapeutic potential. In addition, it also provides a scientific basis for better clinical application of DGNT in the future. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021271607; Identifier: PROSPERO, CRD42021271607. |
format | Online Article Text |
id | pubmed-10426740 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104267402023-08-16 Efficacy and safety of Danggui Niantong Decoction in patients with gout: a systematic review and meta-analysis Peng, Sihan Tian, Jing Jin, Luchang Wang, Hongyan Xie, Chunguang Zheng, Jie Liu, Linfeng Cao, Jun Zhang, Wen Zhang, Xiangeng Front Pharmacol Pharmacology Background: This study aims to evaluate the efficacy and safety of Danggui Niantong Decoction (DGNT) systematically on gout treating. Methods: This study was registered in PROSPERO, and the registration number was CRD42021271607. By the end of December, 2022, literature research was conducted among eight electronic databases. Main results of this study were blood uric acid (BUA) and Creactive protein (CRP). Secondary outcomes were erythrocyte sedimentation rate (ESR), serum creatinine (Scr), urinary protein quantified at 24 h (Upro), and interleukin-8 (IL-8). Study screening, data collection, as well as quality assessment were performed by two reviewers independently, and analysis was completed using Stata (SE15.0) and Review Manager (5.4). Results: A total number of 13 studies were included in our meta-analysis (n = 1,094 participants). Results showed DGNT combined with conventional western medicine (CWM) was more effective than WM alone in BUA (weighted mean differences (WMD) = −3.49, 95% confidence interval (CI) [−50.36, −32.59], p = 0.000), CRP (WMD = −41.48, 95% CI [−4.32, −2.66], p = 0.017), ESR (WMD = −6.23, 95% CI [−9.28, −3.17], p = 0.019), Scr (WMD = −18.64, 95% CI [−23.09, −14.19], p = 0.001), Upro (WMD = −0.72, 95% CI [−0.91, −0.53], p = 0.000), and IL-8 (WMD = −4.77, 95% CI [−11.48, 1.94], p = 0.000). None of the adverse effects noted were severe, and no life-threatening event was reported. Conclusion: This study shows that DGNT combined with CWM seems to have an effective clinical therapeutic potential. In addition, it also provides a scientific basis for better clinical application of DGNT in the future. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021271607; Identifier: PROSPERO, CRD42021271607. Frontiers Media S.A. 2023-07-26 /pmc/articles/PMC10426740/ /pubmed/37587984 http://dx.doi.org/10.3389/fphar.2023.1168863 Text en Copyright © 2023 Peng, Tian, Jin, Wang, Xie, Zheng, Liu, Cao, Zhang and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Peng, Sihan Tian, Jing Jin, Luchang Wang, Hongyan Xie, Chunguang Zheng, Jie Liu, Linfeng Cao, Jun Zhang, Wen Zhang, Xiangeng Efficacy and safety of Danggui Niantong Decoction in patients with gout: a systematic review and meta-analysis |
title | Efficacy and safety of Danggui Niantong Decoction in patients with gout: a systematic review and meta-analysis |
title_full | Efficacy and safety of Danggui Niantong Decoction in patients with gout: a systematic review and meta-analysis |
title_fullStr | Efficacy and safety of Danggui Niantong Decoction in patients with gout: a systematic review and meta-analysis |
title_full_unstemmed | Efficacy and safety of Danggui Niantong Decoction in patients with gout: a systematic review and meta-analysis |
title_short | Efficacy and safety of Danggui Niantong Decoction in patients with gout: a systematic review and meta-analysis |
title_sort | efficacy and safety of danggui niantong decoction in patients with gout: a systematic review and meta-analysis |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426740/ https://www.ncbi.nlm.nih.gov/pubmed/37587984 http://dx.doi.org/10.3389/fphar.2023.1168863 |
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