Single molecule studies characterize the kinetic mechanism of tetrameric p53 binding to different native response elements

The transcriptional activator p53 is a tumor suppressor protein that controls cellular pathways important for cell fate decisions, including cell cycle arrest, senescence, and apoptosis. It functions as a tetramer by binding to specific DNA sequences known as response elements (REs) to control trans...

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Detalles Bibliográficos
Autores principales: Suwita, Johannes P., Voong, Calvin K., Ly, Elina, Goodrich, James A., Kugel, Jennifer F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426914/
https://www.ncbi.nlm.nih.gov/pubmed/37582100
http://dx.doi.org/10.1371/journal.pone.0286193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426914/
https://www.ncbi.nlm.nih.gov/pubmed/37582100
http://dx.doi.org/10.1371/journal.pone.0286193

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