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Single molecule studies characterize the kinetic mechanism of tetrameric p53 binding to different native response elements
The transcriptional activator p53 is a tumor suppressor protein that controls cellular pathways important for cell fate decisions, including cell cycle arrest, senescence, and apoptosis. It functions as a tetramer by binding to specific DNA sequences known as response elements (REs) to control trans...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426914/ https://www.ncbi.nlm.nih.gov/pubmed/37582100 http://dx.doi.org/10.1371/journal.pone.0286193 |