IgG1-3 MuSK Antibodies Inhibit AChR Cluster Formation, Restored by SHP2 Inhibitor, Despite Normal MuSK, DOK7, or AChR Subunit Phosphorylation

BACKGROUND AND OBJECTIVES: Up to 50% of patients with myasthenia gravis (MG) without acetylcholine receptor antibodies (AChR-Abs) have antibodies to muscle-specific kinase (MuSK). Most MuSK antibodies (MuSK-Abs) are IgG4 and inhibit agrin-induced MuSK phosphorylation, leading to impaired clustering...

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Detalles Bibliográficos
Autores principales: Cao, Michelangelo, Liu, Wei-Wei, Maxwell, Susan, Huda, Saif, Webster, Richard, Evoli, Amelia, Beeson, David, Cossins, Judith A., Vincent, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427144/
https://www.ncbi.nlm.nih.gov/pubmed/37582613
http://dx.doi.org/10.1212/NXI.0000000000200147

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