N4‐Acetylcytidine Drives Glycolysis Addiction in Gastric Cancer via NAT10/SEPT9/HIF‐1α Positive Feedback Loop (Adv. Sci. 23/2023)

Gastric Cancer Cover story shows the ancient Chinese story “Nezha Conquers the Dragon King”. In article number 2300898, Fengping Li, Gengtai Ye, Guoxin Li, and co‐workers demonstrate that N4‐acetylcytidine (ac4C) promotes glycolysis addiction through a NAT10/SEPT9/HIF‐1α positive feedback loop in ga...

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Detalles Bibliográficos
Autores principales: Yang, Qingbin, Lei, Xuetao, He, Jiayong, Peng, Yanmei, Zhang, Yihao, Ling, Ruoyu, Wu, Chaorui, Zhang, Guofan, Zheng, Boyang, Chen, Xinhua, Zou, Boya, Fu, Ziyi, Zhao, Liying, Liu, Hao, Hu, Yanfeng, Yu, Jiang, Li, Fengping, Ye, Gengtai, Li, Guoxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Frontispiece
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427349/
http://dx.doi.org/10.1002/advs.202370155
Descripción
Sumario:Gastric Cancer Cover story shows the ancient Chinese story “Nezha Conquers the Dragon King”. In article number 2300898, Fengping Li, Gengtai Ye, Guoxin Li, and co‐workers demonstrate that N4‐acetylcytidine (ac4C) promotes glycolysis addiction through a NAT10/SEPT9/HIF‐1α positive feedback loop in gastric cancer cells, leading to anti‐angiogenic therapy resistance. In the cover, the angiogenesis inhibitor Apatinib (Red Armillary Sash) combined with the N acetyltransferase 10 (NAT10, Dragon Tendon) inhibitor Remodelin attenuates the hypoxia tolerance of gastric cancer cells (Dragon) and inhibits tumor progression. [Image: see text]

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