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N4‐Acetylcytidine Drives Glycolysis Addiction in Gastric Cancer via NAT10/SEPT9/HIF‐1α Positive Feedback Loop (Adv. Sci. 23/2023)
Gastric Cancer Cover story shows the ancient Chinese story “Nezha Conquers the Dragon King”. In article number 2300898, Fengping Li, Gengtai Ye, Guoxin Li, and co‐workers demonstrate that N4‐acetylcytidine (ac4C) promotes glycolysis addiction through a NAT10/SEPT9/HIF‐1α positive feedback loop in ga...
| Autores principales: | , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427349/ http://dx.doi.org/10.1002/advs.202370155 |
| _version_ | 1785090217314615296 |
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| author | Yang, Qingbin Lei, Xuetao He, Jiayong Peng, Yanmei Zhang, Yihao Ling, Ruoyu Wu, Chaorui Zhang, Guofan Zheng, Boyang Chen, Xinhua Zou, Boya Fu, Ziyi Zhao, Liying Liu, Hao Hu, Yanfeng Yu, Jiang Li, Fengping Ye, Gengtai Li, Guoxin |
| author_facet | Yang, Qingbin Lei, Xuetao He, Jiayong Peng, Yanmei Zhang, Yihao Ling, Ruoyu Wu, Chaorui Zhang, Guofan Zheng, Boyang Chen, Xinhua Zou, Boya Fu, Ziyi Zhao, Liying Liu, Hao Hu, Yanfeng Yu, Jiang Li, Fengping Ye, Gengtai Li, Guoxin |
| author_sort | Yang, Qingbin |
| collection | PubMed |
| description | Gastric Cancer Cover story shows the ancient Chinese story “Nezha Conquers the Dragon King”. In article number 2300898, Fengping Li, Gengtai Ye, Guoxin Li, and co‐workers demonstrate that N4‐acetylcytidine (ac4C) promotes glycolysis addiction through a NAT10/SEPT9/HIF‐1α positive feedback loop in gastric cancer cells, leading to anti‐angiogenic therapy resistance. In the cover, the angiogenesis inhibitor Apatinib (Red Armillary Sash) combined with the N acetyltransferase 10 (NAT10, Dragon Tendon) inhibitor Remodelin attenuates the hypoxia tolerance of gastric cancer cells (Dragon) and inhibits tumor progression. [Image: see text] |
| format | Online Article Text |
| id | pubmed-10427349 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-104273492023-08-17 N4‐Acetylcytidine Drives Glycolysis Addiction in Gastric Cancer via NAT10/SEPT9/HIF‐1α Positive Feedback Loop (Adv. Sci. 23/2023) Yang, Qingbin Lei, Xuetao He, Jiayong Peng, Yanmei Zhang, Yihao Ling, Ruoyu Wu, Chaorui Zhang, Guofan Zheng, Boyang Chen, Xinhua Zou, Boya Fu, Ziyi Zhao, Liying Liu, Hao Hu, Yanfeng Yu, Jiang Li, Fengping Ye, Gengtai Li, Guoxin Adv Sci (Weinh) Frontispiece Gastric Cancer Cover story shows the ancient Chinese story “Nezha Conquers the Dragon King”. In article number 2300898, Fengping Li, Gengtai Ye, Guoxin Li, and co‐workers demonstrate that N4‐acetylcytidine (ac4C) promotes glycolysis addiction through a NAT10/SEPT9/HIF‐1α positive feedback loop in gastric cancer cells, leading to anti‐angiogenic therapy resistance. In the cover, the angiogenesis inhibitor Apatinib (Red Armillary Sash) combined with the N acetyltransferase 10 (NAT10, Dragon Tendon) inhibitor Remodelin attenuates the hypoxia tolerance of gastric cancer cells (Dragon) and inhibits tumor progression. [Image: see text] John Wiley and Sons Inc. 2023-08-15 /pmc/articles/PMC10427349/ http://dx.doi.org/10.1002/advs.202370155 Text en © 2023 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| spellingShingle | Frontispiece Yang, Qingbin Lei, Xuetao He, Jiayong Peng, Yanmei Zhang, Yihao Ling, Ruoyu Wu, Chaorui Zhang, Guofan Zheng, Boyang Chen, Xinhua Zou, Boya Fu, Ziyi Zhao, Liying Liu, Hao Hu, Yanfeng Yu, Jiang Li, Fengping Ye, Gengtai Li, Guoxin N4‐Acetylcytidine Drives Glycolysis Addiction in Gastric Cancer via NAT10/SEPT9/HIF‐1α Positive Feedback Loop (Adv. Sci. 23/2023) |
| title | N4‐Acetylcytidine Drives Glycolysis Addiction in Gastric Cancer via NAT10/SEPT9/HIF‐1α Positive Feedback Loop (Adv. Sci. 23/2023) |
| title_full | N4‐Acetylcytidine Drives Glycolysis Addiction in Gastric Cancer via NAT10/SEPT9/HIF‐1α Positive Feedback Loop (Adv. Sci. 23/2023) |
| title_fullStr | N4‐Acetylcytidine Drives Glycolysis Addiction in Gastric Cancer via NAT10/SEPT9/HIF‐1α Positive Feedback Loop (Adv. Sci. 23/2023) |
| title_full_unstemmed | N4‐Acetylcytidine Drives Glycolysis Addiction in Gastric Cancer via NAT10/SEPT9/HIF‐1α Positive Feedback Loop (Adv. Sci. 23/2023) |
| title_short | N4‐Acetylcytidine Drives Glycolysis Addiction in Gastric Cancer via NAT10/SEPT9/HIF‐1α Positive Feedback Loop (Adv. Sci. 23/2023) |
| title_sort | n4‐acetylcytidine drives glycolysis addiction in gastric cancer via nat10/sept9/hif‐1α positive feedback loop (adv. sci. 23/2023) |
| topic | Frontispiece |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427349/ http://dx.doi.org/10.1002/advs.202370155 |
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