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Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer

Colorectal cancer (CRC) is the most common cancer of the digestive system with high mortality and morbidity rates. Gut microbiota is found in the intestines, especially the colorectum, and has structured crosstalk interactions with the host that affect several physiological processes. The gut microb...

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Autores principales: Qu, Ruize, Zhang, Yi, Ma, Yanpeng, Zhou, Xin, Sun, Lulu, Jiang, Changtao, Zhang, Zhipeng, Fu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427379/
https://www.ncbi.nlm.nih.gov/pubmed/37263983
http://dx.doi.org/10.1002/advs.202205563
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author Qu, Ruize
Zhang, Yi
Ma, Yanpeng
Zhou, Xin
Sun, Lulu
Jiang, Changtao
Zhang, Zhipeng
Fu, Wei
author_facet Qu, Ruize
Zhang, Yi
Ma, Yanpeng
Zhou, Xin
Sun, Lulu
Jiang, Changtao
Zhang, Zhipeng
Fu, Wei
author_sort Qu, Ruize
collection PubMed
description Colorectal cancer (CRC) is the most common cancer of the digestive system with high mortality and morbidity rates. Gut microbiota is found in the intestines, especially the colorectum, and has structured crosstalk interactions with the host that affect several physiological processes. The gut microbiota include CRC‐promoting bacterial species, such as Fusobacterium nucleatum, Escherichia coli, and Bacteroides fragilis, and CRC‐protecting bacterial species, such as Clostridium butyricum, Streptococcus thermophilus, and Lacticaseibacillus paracasei, which along with other microorganisms, such as viruses and fungi, play critical roles in the development of CRC. Different bacterial features are identified in patients with early‐onset CRC, combined with different patterns between fecal and intratumoral microbiota. The gut microbiota may be beneficial in the diagnosis and treatment of CRC; some bacteria may serve as biomarkers while others as regulators of chemotherapy and immunotherapy. Furthermore, metabolites produced by the gut microbiota play essential roles in the crosstalk with CRC cells. Harmful metabolites include some primary bile acids and short‐chain fatty acids, whereas others, including ursodeoxycholic acid and butyrate, are beneficial and impede tumor development and progression. This review focuses on the gut microbiota and its metabolites, and their potential roles in the development, diagnosis, and treatment of CRC.
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spelling pubmed-104273792023-08-17 Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer Qu, Ruize Zhang, Yi Ma, Yanpeng Zhou, Xin Sun, Lulu Jiang, Changtao Zhang, Zhipeng Fu, Wei Adv Sci (Weinh) Reviews Colorectal cancer (CRC) is the most common cancer of the digestive system with high mortality and morbidity rates. Gut microbiota is found in the intestines, especially the colorectum, and has structured crosstalk interactions with the host that affect several physiological processes. The gut microbiota include CRC‐promoting bacterial species, such as Fusobacterium nucleatum, Escherichia coli, and Bacteroides fragilis, and CRC‐protecting bacterial species, such as Clostridium butyricum, Streptococcus thermophilus, and Lacticaseibacillus paracasei, which along with other microorganisms, such as viruses and fungi, play critical roles in the development of CRC. Different bacterial features are identified in patients with early‐onset CRC, combined with different patterns between fecal and intratumoral microbiota. The gut microbiota may be beneficial in the diagnosis and treatment of CRC; some bacteria may serve as biomarkers while others as regulators of chemotherapy and immunotherapy. Furthermore, metabolites produced by the gut microbiota play essential roles in the crosstalk with CRC cells. Harmful metabolites include some primary bile acids and short‐chain fatty acids, whereas others, including ursodeoxycholic acid and butyrate, are beneficial and impede tumor development and progression. This review focuses on the gut microbiota and its metabolites, and their potential roles in the development, diagnosis, and treatment of CRC. John Wiley and Sons Inc. 2023-06-01 /pmc/articles/PMC10427379/ /pubmed/37263983 http://dx.doi.org/10.1002/advs.202205563 Text en © 2023 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Qu, Ruize
Zhang, Yi
Ma, Yanpeng
Zhou, Xin
Sun, Lulu
Jiang, Changtao
Zhang, Zhipeng
Fu, Wei
Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer
title Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer
title_full Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer
title_fullStr Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer
title_full_unstemmed Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer
title_short Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer
title_sort role of the gut microbiota and its metabolites in tumorigenesis or development of colorectal cancer
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427379/
https://www.ncbi.nlm.nih.gov/pubmed/37263983
http://dx.doi.org/10.1002/advs.202205563
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