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Systematic Mining and Evaluation of the Sesquiterpene Skeletons as High Energy Aviation Fuel Molecules
Sesquiterpenes have been identified as promising ingredients for aviation fuels due to their high energy density and combustion heat properties. Despite the characterization of numerous sesquiterpene structures, studies testing their performance properties and feasibility as fuels are scarce. In thi...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427387/ https://www.ncbi.nlm.nih.gov/pubmed/37271925 http://dx.doi.org/10.1002/advs.202300889 |
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author | Huang, Yanglei Ye, Ziling Wan, Xiukun Yao, Ge Duan, Jingyu Liu, Jiajia Yao, Mingdong Sun, Xiang Deng, Zixin Shen, Kun Jiang, Hui Liu, Tiangang |
author_facet | Huang, Yanglei Ye, Ziling Wan, Xiukun Yao, Ge Duan, Jingyu Liu, Jiajia Yao, Mingdong Sun, Xiang Deng, Zixin Shen, Kun Jiang, Hui Liu, Tiangang |
author_sort | Huang, Yanglei |
collection | PubMed |
description | Sesquiterpenes have been identified as promising ingredients for aviation fuels due to their high energy density and combustion heat properties. Despite the characterization of numerous sesquiterpene structures, studies testing their performance properties and feasibility as fuels are scarce. In this study, 122 sesquiterpenoid skeleton compounds, obtained from existing literature reports, are tested using group contribution and gaussian quantum chemistry methods to assess their potential as high‐energy aviation fuels. Seventeen sesquiterpene compounds exhibit good predictive performance and nine compounds are further selected for overproduction in yeast. Through fed‐batch fermentation, all compounds achieve the highest reported titers to date. Subsequently, three representative products, pentalenene, presilphiperfol‐1‐ene, and α‐farnesene, are selected, produced, purified in large quantities, and tested for use as potential fuels. The performance of pentalenene, presilphiperfol‐1‐ene, and their derivatives reveals favorable prospects as high‐energy aviation fuels. |
format | Online Article Text |
id | pubmed-10427387 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104273872023-08-17 Systematic Mining and Evaluation of the Sesquiterpene Skeletons as High Energy Aviation Fuel Molecules Huang, Yanglei Ye, Ziling Wan, Xiukun Yao, Ge Duan, Jingyu Liu, Jiajia Yao, Mingdong Sun, Xiang Deng, Zixin Shen, Kun Jiang, Hui Liu, Tiangang Adv Sci (Weinh) Research Articles Sesquiterpenes have been identified as promising ingredients for aviation fuels due to their high energy density and combustion heat properties. Despite the characterization of numerous sesquiterpene structures, studies testing their performance properties and feasibility as fuels are scarce. In this study, 122 sesquiterpenoid skeleton compounds, obtained from existing literature reports, are tested using group contribution and gaussian quantum chemistry methods to assess their potential as high‐energy aviation fuels. Seventeen sesquiterpene compounds exhibit good predictive performance and nine compounds are further selected for overproduction in yeast. Through fed‐batch fermentation, all compounds achieve the highest reported titers to date. Subsequently, three representative products, pentalenene, presilphiperfol‐1‐ene, and α‐farnesene, are selected, produced, purified in large quantities, and tested for use as potential fuels. The performance of pentalenene, presilphiperfol‐1‐ene, and their derivatives reveals favorable prospects as high‐energy aviation fuels. John Wiley and Sons Inc. 2023-06-04 /pmc/articles/PMC10427387/ /pubmed/37271925 http://dx.doi.org/10.1002/advs.202300889 Text en © 2023 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Huang, Yanglei Ye, Ziling Wan, Xiukun Yao, Ge Duan, Jingyu Liu, Jiajia Yao, Mingdong Sun, Xiang Deng, Zixin Shen, Kun Jiang, Hui Liu, Tiangang Systematic Mining and Evaluation of the Sesquiterpene Skeletons as High Energy Aviation Fuel Molecules |
title | Systematic Mining and Evaluation of the Sesquiterpene Skeletons as High Energy Aviation Fuel Molecules |
title_full | Systematic Mining and Evaluation of the Sesquiterpene Skeletons as High Energy Aviation Fuel Molecules |
title_fullStr | Systematic Mining and Evaluation of the Sesquiterpene Skeletons as High Energy Aviation Fuel Molecules |
title_full_unstemmed | Systematic Mining and Evaluation of the Sesquiterpene Skeletons as High Energy Aviation Fuel Molecules |
title_short | Systematic Mining and Evaluation of the Sesquiterpene Skeletons as High Energy Aviation Fuel Molecules |
title_sort | systematic mining and evaluation of the sesquiterpene skeletons as high energy aviation fuel molecules |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427387/ https://www.ncbi.nlm.nih.gov/pubmed/37271925 http://dx.doi.org/10.1002/advs.202300889 |
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