Cargando…

Systematic Mining and Evaluation of the Sesquiterpene Skeletons as High Energy Aviation Fuel Molecules

Sesquiterpenes have been identified as promising ingredients for aviation fuels due to their high energy density and combustion heat properties. Despite the characterization of numerous sesquiterpene structures, studies testing their performance properties and feasibility as fuels are scarce. In thi...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Yanglei, Ye, Ziling, Wan, Xiukun, Yao, Ge, Duan, Jingyu, Liu, Jiajia, Yao, Mingdong, Sun, Xiang, Deng, Zixin, Shen, Kun, Jiang, Hui, Liu, Tiangang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427387/
https://www.ncbi.nlm.nih.gov/pubmed/37271925
http://dx.doi.org/10.1002/advs.202300889
_version_ 1785090227593805824
author Huang, Yanglei
Ye, Ziling
Wan, Xiukun
Yao, Ge
Duan, Jingyu
Liu, Jiajia
Yao, Mingdong
Sun, Xiang
Deng, Zixin
Shen, Kun
Jiang, Hui
Liu, Tiangang
author_facet Huang, Yanglei
Ye, Ziling
Wan, Xiukun
Yao, Ge
Duan, Jingyu
Liu, Jiajia
Yao, Mingdong
Sun, Xiang
Deng, Zixin
Shen, Kun
Jiang, Hui
Liu, Tiangang
author_sort Huang, Yanglei
collection PubMed
description Sesquiterpenes have been identified as promising ingredients for aviation fuels due to their high energy density and combustion heat properties. Despite the characterization of numerous sesquiterpene structures, studies testing their performance properties and feasibility as fuels are scarce. In this study, 122 sesquiterpenoid skeleton compounds, obtained from existing literature reports, are tested using group contribution and gaussian quantum chemistry methods to assess their potential as high‐energy aviation fuels. Seventeen sesquiterpene compounds exhibit good predictive performance and nine compounds are further selected for overproduction in yeast. Through fed‐batch fermentation, all compounds achieve the highest reported titers to date. Subsequently, three representative products, pentalenene, presilphiperfol‐1‐ene, and α‐farnesene, are selected, produced, purified in large quantities, and tested for use as potential fuels. The performance of pentalenene, presilphiperfol‐1‐ene, and their derivatives reveals favorable prospects as high‐energy aviation fuels.
format Online
Article
Text
id pubmed-10427387
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-104273872023-08-17 Systematic Mining and Evaluation of the Sesquiterpene Skeletons as High Energy Aviation Fuel Molecules Huang, Yanglei Ye, Ziling Wan, Xiukun Yao, Ge Duan, Jingyu Liu, Jiajia Yao, Mingdong Sun, Xiang Deng, Zixin Shen, Kun Jiang, Hui Liu, Tiangang Adv Sci (Weinh) Research Articles Sesquiterpenes have been identified as promising ingredients for aviation fuels due to their high energy density and combustion heat properties. Despite the characterization of numerous sesquiterpene structures, studies testing their performance properties and feasibility as fuels are scarce. In this study, 122 sesquiterpenoid skeleton compounds, obtained from existing literature reports, are tested using group contribution and gaussian quantum chemistry methods to assess their potential as high‐energy aviation fuels. Seventeen sesquiterpene compounds exhibit good predictive performance and nine compounds are further selected for overproduction in yeast. Through fed‐batch fermentation, all compounds achieve the highest reported titers to date. Subsequently, three representative products, pentalenene, presilphiperfol‐1‐ene, and α‐farnesene, are selected, produced, purified in large quantities, and tested for use as potential fuels. The performance of pentalenene, presilphiperfol‐1‐ene, and their derivatives reveals favorable prospects as high‐energy aviation fuels. John Wiley and Sons Inc. 2023-06-04 /pmc/articles/PMC10427387/ /pubmed/37271925 http://dx.doi.org/10.1002/advs.202300889 Text en © 2023 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Huang, Yanglei
Ye, Ziling
Wan, Xiukun
Yao, Ge
Duan, Jingyu
Liu, Jiajia
Yao, Mingdong
Sun, Xiang
Deng, Zixin
Shen, Kun
Jiang, Hui
Liu, Tiangang
Systematic Mining and Evaluation of the Sesquiterpene Skeletons as High Energy Aviation Fuel Molecules
title Systematic Mining and Evaluation of the Sesquiterpene Skeletons as High Energy Aviation Fuel Molecules
title_full Systematic Mining and Evaluation of the Sesquiterpene Skeletons as High Energy Aviation Fuel Molecules
title_fullStr Systematic Mining and Evaluation of the Sesquiterpene Skeletons as High Energy Aviation Fuel Molecules
title_full_unstemmed Systematic Mining and Evaluation of the Sesquiterpene Skeletons as High Energy Aviation Fuel Molecules
title_short Systematic Mining and Evaluation of the Sesquiterpene Skeletons as High Energy Aviation Fuel Molecules
title_sort systematic mining and evaluation of the sesquiterpene skeletons as high energy aviation fuel molecules
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427387/
https://www.ncbi.nlm.nih.gov/pubmed/37271925
http://dx.doi.org/10.1002/advs.202300889
work_keys_str_mv AT huangyanglei systematicminingandevaluationofthesesquiterpeneskeletonsashighenergyaviationfuelmolecules
AT yeziling systematicminingandevaluationofthesesquiterpeneskeletonsashighenergyaviationfuelmolecules
AT wanxiukun systematicminingandevaluationofthesesquiterpeneskeletonsashighenergyaviationfuelmolecules
AT yaoge systematicminingandevaluationofthesesquiterpeneskeletonsashighenergyaviationfuelmolecules
AT duanjingyu systematicminingandevaluationofthesesquiterpeneskeletonsashighenergyaviationfuelmolecules
AT liujiajia systematicminingandevaluationofthesesquiterpeneskeletonsashighenergyaviationfuelmolecules
AT yaomingdong systematicminingandevaluationofthesesquiterpeneskeletonsashighenergyaviationfuelmolecules
AT sunxiang systematicminingandevaluationofthesesquiterpeneskeletonsashighenergyaviationfuelmolecules
AT dengzixin systematicminingandevaluationofthesesquiterpeneskeletonsashighenergyaviationfuelmolecules
AT shenkun systematicminingandevaluationofthesesquiterpeneskeletonsashighenergyaviationfuelmolecules
AT jianghui systematicminingandevaluationofthesesquiterpeneskeletonsashighenergyaviationfuelmolecules
AT liutiangang systematicminingandevaluationofthesesquiterpeneskeletonsashighenergyaviationfuelmolecules