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Metformin escape in prostate cancer by activating the PTGR1 transcriptional program through a novel super-enhancer
The therapeutic efficacy of metformin in prostate cancer (PCa) appears uncertain based on various clinical trials. Metformin treatment failure may be attributed to the high frequency of transcriptional dysregulation, which leads to drug resistance. However, the underlying mechanism is still unclear....
Autores principales: | Ye, Jianheng, Cai, Shanghua, Feng, Yuanfa, Li, Jinchuang, Cai, Zhiduan, Deng, Yulin, Liu, Ren, Zhu, Xuejin, Lu, Jianming, Zhuo, Yangjia, Liang, Yingke, Xie, Jianjiang, Zhang, Yanqiong, He, Huichan, Han, Zhaodong, Jia, Zhenyu, Zhong, Weide |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427640/ https://www.ncbi.nlm.nih.gov/pubmed/37582751 http://dx.doi.org/10.1038/s41392-023-01516-2 |
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