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Genomic diversity of Yersinia pestis from Yunnan Province, China, implies a potential common ancestor as the source of two plague epidemics
Plague, caused by Yersinia pestis, is a zoonotic disease that can reemerge and cause outbreaks following decades of latency in natural plague foci. However, the genetic diversity and spread pattern of Y. pestis during these epidemic-silent cycles remain unclear. In this study, we analyze 356 Y. pest...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427647/ https://www.ncbi.nlm.nih.gov/pubmed/37582843 http://dx.doi.org/10.1038/s42003-023-05186-2 |
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author | Qin, Jingliang Wu, Yarong Shi, Liyuan Zuo, Xiujuan Zhang, Xianglilan Qian, Xiuwei Fan, Hang Guo, Yan Cui, Mengnan Zhang, Haipeng Yang, Fengyi Kong, Jinjiao Song, Yajun Yang, Ruifu Wang, Peng Cui, Yujun |
author_facet | Qin, Jingliang Wu, Yarong Shi, Liyuan Zuo, Xiujuan Zhang, Xianglilan Qian, Xiuwei Fan, Hang Guo, Yan Cui, Mengnan Zhang, Haipeng Yang, Fengyi Kong, Jinjiao Song, Yajun Yang, Ruifu Wang, Peng Cui, Yujun |
author_sort | Qin, Jingliang |
collection | PubMed |
description | Plague, caused by Yersinia pestis, is a zoonotic disease that can reemerge and cause outbreaks following decades of latency in natural plague foci. However, the genetic diversity and spread pattern of Y. pestis during these epidemic-silent cycles remain unclear. In this study, we analyze 356 Y. pestis genomes isolated between 1952 and 2016 in the Yunnan Rattus tanezumi plague focus, China, covering two epidemic-silent cycles. Through high-resolution genomic epidemiological analysis, we find that 96% of Y. pestis genomes belong to phylogroup 1.ORI2 and are subdivided into two sister clades (Sublineage1 and Sublineage2) characterized by different temporal-spatial distributions and genetic diversity. Most of the Sublineage1 strains are isolated from the first epidemic-silent cycle, while Sublineage2 strains are predominantly from the second cycle and revealing a west to east spread. The two sister clades evolved in parallel from a common ancestor and independently lead to two separate epidemics, confirming that the pathogen responsible for the second epidemic following the silent interval is not a descendant of the causative strain of the first epidemic. Our results provide a mechanism for defining epidemic-silent cycles in natural plague foci, which is valuable in the prevention and control of future plague outbreaks. |
format | Online Article Text |
id | pubmed-10427647 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-104276472023-08-17 Genomic diversity of Yersinia pestis from Yunnan Province, China, implies a potential common ancestor as the source of two plague epidemics Qin, Jingliang Wu, Yarong Shi, Liyuan Zuo, Xiujuan Zhang, Xianglilan Qian, Xiuwei Fan, Hang Guo, Yan Cui, Mengnan Zhang, Haipeng Yang, Fengyi Kong, Jinjiao Song, Yajun Yang, Ruifu Wang, Peng Cui, Yujun Commun Biol Article Plague, caused by Yersinia pestis, is a zoonotic disease that can reemerge and cause outbreaks following decades of latency in natural plague foci. However, the genetic diversity and spread pattern of Y. pestis during these epidemic-silent cycles remain unclear. In this study, we analyze 356 Y. pestis genomes isolated between 1952 and 2016 in the Yunnan Rattus tanezumi plague focus, China, covering two epidemic-silent cycles. Through high-resolution genomic epidemiological analysis, we find that 96% of Y. pestis genomes belong to phylogroup 1.ORI2 and are subdivided into two sister clades (Sublineage1 and Sublineage2) characterized by different temporal-spatial distributions and genetic diversity. Most of the Sublineage1 strains are isolated from the first epidemic-silent cycle, while Sublineage2 strains are predominantly from the second cycle and revealing a west to east spread. The two sister clades evolved in parallel from a common ancestor and independently lead to two separate epidemics, confirming that the pathogen responsible for the second epidemic following the silent interval is not a descendant of the causative strain of the first epidemic. Our results provide a mechanism for defining epidemic-silent cycles in natural plague foci, which is valuable in the prevention and control of future plague outbreaks. Nature Publishing Group UK 2023-08-15 /pmc/articles/PMC10427647/ /pubmed/37582843 http://dx.doi.org/10.1038/s42003-023-05186-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Qin, Jingliang Wu, Yarong Shi, Liyuan Zuo, Xiujuan Zhang, Xianglilan Qian, Xiuwei Fan, Hang Guo, Yan Cui, Mengnan Zhang, Haipeng Yang, Fengyi Kong, Jinjiao Song, Yajun Yang, Ruifu Wang, Peng Cui, Yujun Genomic diversity of Yersinia pestis from Yunnan Province, China, implies a potential common ancestor as the source of two plague epidemics |
title | Genomic diversity of Yersinia pestis from Yunnan Province, China, implies a potential common ancestor as the source of two plague epidemics |
title_full | Genomic diversity of Yersinia pestis from Yunnan Province, China, implies a potential common ancestor as the source of two plague epidemics |
title_fullStr | Genomic diversity of Yersinia pestis from Yunnan Province, China, implies a potential common ancestor as the source of two plague epidemics |
title_full_unstemmed | Genomic diversity of Yersinia pestis from Yunnan Province, China, implies a potential common ancestor as the source of two plague epidemics |
title_short | Genomic diversity of Yersinia pestis from Yunnan Province, China, implies a potential common ancestor as the source of two plague epidemics |
title_sort | genomic diversity of yersinia pestis from yunnan province, china, implies a potential common ancestor as the source of two plague epidemics |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427647/ https://www.ncbi.nlm.nih.gov/pubmed/37582843 http://dx.doi.org/10.1038/s42003-023-05186-2 |
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