mRNA 3’UTR lengthening by alternative polyadenylation attenuates inflammatory responses and correlates with virulence of Influenza A virus

Changes of mRNA 3’UTRs by alternative polyadenylation (APA) have been associated to numerous pathologies, but the mechanisms and consequences often remain enigmatic. By combining transcriptomics, proteomics and recombinant viruses we show that all tested strains of IAV, including A/PR/8/34(H1N1) (PR...

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Detalles Bibliográficos
Autores principales: Bergant, Valter, Schnepf, Daniel, de Andrade Krätzig, Niklas, Hubel, Philipp, Urban, Christian, Engleitner, Thomas, Dijkman, Ronald, Ryffel, Bernhard, Steiger, Katja, Knolle, Percy A., Kochs, Georg, Rad, Roland, Staeheli, Peter, Pichlmair, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427651/
https://www.ncbi.nlm.nih.gov/pubmed/37582777
http://dx.doi.org/10.1038/s41467-023-40469-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427651/
https://www.ncbi.nlm.nih.gov/pubmed/37582777
http://dx.doi.org/10.1038/s41467-023-40469-6

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