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Neural representations of anxiety in adolescents with anorexia nervosa: a multivariate approach

Anorexia nervosa (AN) is characterized by low body weight, fear of gaining weight, and distorted body image. Anxiety may play a role in the formation and course of the illness, especially related to situations involving food, eating, weight, and body image. To understand distributed patterns and con...

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Autores principales: Seiger, René, Reggente, Nicco, Majid, D.S.-Adnan, Ly, Ronald, Tadayonnejad, Reza, Strober, Michael, Feusner, Jamie D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427677/
https://www.ncbi.nlm.nih.gov/pubmed/37582758
http://dx.doi.org/10.1038/s41398-023-02581-5
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author Seiger, René
Reggente, Nicco
Majid, D.S.-Adnan
Ly, Ronald
Tadayonnejad, Reza
Strober, Michael
Feusner, Jamie D.
author_facet Seiger, René
Reggente, Nicco
Majid, D.S.-Adnan
Ly, Ronald
Tadayonnejad, Reza
Strober, Michael
Feusner, Jamie D.
author_sort Seiger, René
collection PubMed
description Anorexia nervosa (AN) is characterized by low body weight, fear of gaining weight, and distorted body image. Anxiety may play a role in the formation and course of the illness, especially related to situations involving food, eating, weight, and body image. To understand distributed patterns and consistency of neural responses related to anxiety, we enrolled 25 female adolescents with AN and 22 non-clinical female adolescents with mild anxiety who underwent two fMRI sessions in which they saw personalized anxiety-provoking word stimuli and neutral words. Consistency in brain response patterns across trials was determined using a multivariate representational similarity analysis (RSA) approach within anxiety circuits and in a whole-brain voxel-wise searchlight analysis. In the AN group there was higher representational similarity for anxiety-provoking compared with neutral stimuli predominantly in prefrontal regions including the frontal pole, medial prefrontal cortex, dorsolateral prefrontal cortex, and medial orbitofrontal cortex, although no significant group differences. Severity of anxiety correlated with consistency of brain responses within anxiety circuits and in cortical and subcortical regions including the frontal pole, middle frontal gyrus, orbitofrontal cortex, thalamus, lateral occipital cortex, middle temporal gyrus, and cerebellum. Higher consistency of activation in those with more severe anxiety symptoms suggests the possibility of a greater degree of conditioned brain responses evoked by personally-relevant emotional stimuli. Anxiety elicited by disorder-related stimuli may activate stereotyped, previously-learned neural responses within- and outside of classical anxiety circuits. Results have implications for understanding consistent and automatic responding to environmental stimuli that may play a role in maintenance of AN.
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spelling pubmed-104276772023-08-17 Neural representations of anxiety in adolescents with anorexia nervosa: a multivariate approach Seiger, René Reggente, Nicco Majid, D.S.-Adnan Ly, Ronald Tadayonnejad, Reza Strober, Michael Feusner, Jamie D. Transl Psychiatry Article Anorexia nervosa (AN) is characterized by low body weight, fear of gaining weight, and distorted body image. Anxiety may play a role in the formation and course of the illness, especially related to situations involving food, eating, weight, and body image. To understand distributed patterns and consistency of neural responses related to anxiety, we enrolled 25 female adolescents with AN and 22 non-clinical female adolescents with mild anxiety who underwent two fMRI sessions in which they saw personalized anxiety-provoking word stimuli and neutral words. Consistency in brain response patterns across trials was determined using a multivariate representational similarity analysis (RSA) approach within anxiety circuits and in a whole-brain voxel-wise searchlight analysis. In the AN group there was higher representational similarity for anxiety-provoking compared with neutral stimuli predominantly in prefrontal regions including the frontal pole, medial prefrontal cortex, dorsolateral prefrontal cortex, and medial orbitofrontal cortex, although no significant group differences. Severity of anxiety correlated with consistency of brain responses within anxiety circuits and in cortical and subcortical regions including the frontal pole, middle frontal gyrus, orbitofrontal cortex, thalamus, lateral occipital cortex, middle temporal gyrus, and cerebellum. Higher consistency of activation in those with more severe anxiety symptoms suggests the possibility of a greater degree of conditioned brain responses evoked by personally-relevant emotional stimuli. Anxiety elicited by disorder-related stimuli may activate stereotyped, previously-learned neural responses within- and outside of classical anxiety circuits. Results have implications for understanding consistent and automatic responding to environmental stimuli that may play a role in maintenance of AN. Nature Publishing Group UK 2023-08-15 /pmc/articles/PMC10427677/ /pubmed/37582758 http://dx.doi.org/10.1038/s41398-023-02581-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Seiger, René
Reggente, Nicco
Majid, D.S.-Adnan
Ly, Ronald
Tadayonnejad, Reza
Strober, Michael
Feusner, Jamie D.
Neural representations of anxiety in adolescents with anorexia nervosa: a multivariate approach
title Neural representations of anxiety in adolescents with anorexia nervosa: a multivariate approach
title_full Neural representations of anxiety in adolescents with anorexia nervosa: a multivariate approach
title_fullStr Neural representations of anxiety in adolescents with anorexia nervosa: a multivariate approach
title_full_unstemmed Neural representations of anxiety in adolescents with anorexia nervosa: a multivariate approach
title_short Neural representations of anxiety in adolescents with anorexia nervosa: a multivariate approach
title_sort neural representations of anxiety in adolescents with anorexia nervosa: a multivariate approach
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427677/
https://www.ncbi.nlm.nih.gov/pubmed/37582758
http://dx.doi.org/10.1038/s41398-023-02581-5
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