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Betaine attenuates oxidative stress and cognitive dysfunction in an amyloid β-induced rat model of Alzheimer’s disease

BACKGROUND AND PURPOSE: Increasing evidence indicates that oxidative stress is an important factor in the pathogenesis and progression of Alzheimer’s disease (AD). Betaine is trimethylglycine with antioxidant and neuroprotective properties. The present study aimed to evaluate the possible beneficial...

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Autores principales: Alipourfard, Fatemeh, Shajiee, Hooman, Nazari-Serenjeh, Farzaneh, Hojati, Vida, Alirezaie, Masoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427792/
https://www.ncbi.nlm.nih.gov/pubmed/37593165
http://dx.doi.org/10.4103/1735-5362.371583
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author Alipourfard, Fatemeh
Shajiee, Hooman
Nazari-Serenjeh, Farzaneh
Hojati, Vida
Alirezaie, Masoud
author_facet Alipourfard, Fatemeh
Shajiee, Hooman
Nazari-Serenjeh, Farzaneh
Hojati, Vida
Alirezaie, Masoud
author_sort Alipourfard, Fatemeh
collection PubMed
description BACKGROUND AND PURPOSE: Increasing evidence indicates that oxidative stress is an important factor in the pathogenesis and progression of Alzheimer’s disease (AD). Betaine is trimethylglycine with antioxidant and neuroprotective properties. The present study aimed to evaluate the possible beneficial effects of betaine on oxidative stress and memory deficits induced by intrahippocampal injection of amyloid beta (Aß) in an AD model. EXPERIMENTAL APPROACH: Forty adult male Wistar rats were divided into 5 equal groups: the control and Aß groups which received oral gavage of saline (1 mL daily) for 14 days. The other 3 groups (betaine + Aß) received betaine (5, 10, and 15 mg/kg, orally) for 14 consecutive days. On the 15(th) day, all of the groups were injected bilaterallyintrahippocampal of Aß (5 µg/µL), except controls that were injected with normal saline as a vehicle. Seven days after the Aß injection, memory was assessed in a passive avoidance test. Changes in catalase activities and glutathione peroxidase, glutathione, and malondialdehyde concentrations were investigated to determine the antioxidant activity in the rat hippocampus. FINDINGS/RESULTS: Data showed that betaine pretreatment of Aß-injected rats improved memory in avoidance tasks. In addition, betaine pretreatment attenuated oxidative stress. CONCLUSION AND IMPLICATIONS: The current findings showed that oral administration of betaine could prevent Aß-induced impairment of memory possibly through suppression of oxidative stress in the hippocampus area of rats.
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spelling pubmed-104277922023-08-17 Betaine attenuates oxidative stress and cognitive dysfunction in an amyloid β-induced rat model of Alzheimer’s disease Alipourfard, Fatemeh Shajiee, Hooman Nazari-Serenjeh, Farzaneh Hojati, Vida Alirezaie, Masoud Res Pharm Sci Original Article BACKGROUND AND PURPOSE: Increasing evidence indicates that oxidative stress is an important factor in the pathogenesis and progression of Alzheimer’s disease (AD). Betaine is trimethylglycine with antioxidant and neuroprotective properties. The present study aimed to evaluate the possible beneficial effects of betaine on oxidative stress and memory deficits induced by intrahippocampal injection of amyloid beta (Aß) in an AD model. EXPERIMENTAL APPROACH: Forty adult male Wistar rats were divided into 5 equal groups: the control and Aß groups which received oral gavage of saline (1 mL daily) for 14 days. The other 3 groups (betaine + Aß) received betaine (5, 10, and 15 mg/kg, orally) for 14 consecutive days. On the 15(th) day, all of the groups were injected bilaterallyintrahippocampal of Aß (5 µg/µL), except controls that were injected with normal saline as a vehicle. Seven days after the Aß injection, memory was assessed in a passive avoidance test. Changes in catalase activities and glutathione peroxidase, glutathione, and malondialdehyde concentrations were investigated to determine the antioxidant activity in the rat hippocampus. FINDINGS/RESULTS: Data showed that betaine pretreatment of Aß-injected rats improved memory in avoidance tasks. In addition, betaine pretreatment attenuated oxidative stress. CONCLUSION AND IMPLICATIONS: The current findings showed that oral administration of betaine could prevent Aß-induced impairment of memory possibly through suppression of oxidative stress in the hippocampus area of rats. Wolters Kluwer - Medknow 2023-03-10 /pmc/articles/PMC10427792/ /pubmed/37593165 http://dx.doi.org/10.4103/1735-5362.371583 Text en Copyright: © 2023 Research in Pharmaceutical Sciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Alipourfard, Fatemeh
Shajiee, Hooman
Nazari-Serenjeh, Farzaneh
Hojati, Vida
Alirezaie, Masoud
Betaine attenuates oxidative stress and cognitive dysfunction in an amyloid β-induced rat model of Alzheimer’s disease
title Betaine attenuates oxidative stress and cognitive dysfunction in an amyloid β-induced rat model of Alzheimer’s disease
title_full Betaine attenuates oxidative stress and cognitive dysfunction in an amyloid β-induced rat model of Alzheimer’s disease
title_fullStr Betaine attenuates oxidative stress and cognitive dysfunction in an amyloid β-induced rat model of Alzheimer’s disease
title_full_unstemmed Betaine attenuates oxidative stress and cognitive dysfunction in an amyloid β-induced rat model of Alzheimer’s disease
title_short Betaine attenuates oxidative stress and cognitive dysfunction in an amyloid β-induced rat model of Alzheimer’s disease
title_sort betaine attenuates oxidative stress and cognitive dysfunction in an amyloid β-induced rat model of alzheimer’s disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427792/
https://www.ncbi.nlm.nih.gov/pubmed/37593165
http://dx.doi.org/10.4103/1735-5362.371583
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