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Loss of normal Alzheimer's disease-associated Presenilin 2 function alters antiseizure medicine potency and tolerability in the 6-Hz focal seizure model

INTRODUCTION: Patients with early-onset Alzheimer's disease (EOAD) experience seizures and subclinical epileptiform activity, which may accelerate cognitive and functional decline. Antiseizure medicines (ASMs) may be a tractable disease-modifying strategy; numerous ASMs are marketed with well-e...

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Detalles Bibliográficos
Autores principales:	Lehmann, Leanne M., Barker-Haliski, Melissa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Neurology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427874/ https://www.ncbi.nlm.nih.gov/pubmed/37592944 http://dx.doi.org/10.3389/fneur.2023.1223472

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