Inhibition of GSDMD activation by Z-LLSD-FMK or Z-YVAD-FMK reduces vascular inflammation and atherosclerotic lesion development in ApoE(−/−) mice

Pyroptosis is a form of pro-inflammatory cell death that can be mediated by gasdermin D (GSDMD) activation induced by inflammatory caspases such as caspase-1. Emerging evidence suggests that targeting GSDMD activation or pyroptosis may facilitate the reduction of vascular inflammation and atheroscle...

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Detalles Bibliográficos
Autores principales: Zhang, Bao-Li, Yu, Peng, Su, En-Yong, Zhang, Chun-Yu, Xie, Shi-Yao, Yang, Xue, Zou, Yun-Zeng, Liu, Ming, Jiang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427923/
https://www.ncbi.nlm.nih.gov/pubmed/37593179
http://dx.doi.org/10.3389/fphar.2023.1184588

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427923/
https://www.ncbi.nlm.nih.gov/pubmed/37593179
http://dx.doi.org/10.3389/fphar.2023.1184588

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