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Vitamin D alleviates hypothyroidism associated liver dysfunction: Histological and biochemical evidence
There is a complex correlation between thyroid hormones (THs) and liver function. Hypothyroidism as a failure of the thyroid gland to produce adequate thyroid hormones to fulfill the metabolic requirements of the body, may perturb liver structure and function. Emerging evidence suggests the protecti...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10428045/ https://www.ncbi.nlm.nih.gov/pubmed/37593614 http://dx.doi.org/10.1016/j.heliyon.2023.e18860 |
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author | Rastegar-Moghaddam, Seyed Hamidreza Akbarian, Mahsan Rajabian, Arezoo Alipour, Fatemeh Ebrahimzadeh bideskan, Alireza Hosseini, Mahmoud |
author_facet | Rastegar-Moghaddam, Seyed Hamidreza Akbarian, Mahsan Rajabian, Arezoo Alipour, Fatemeh Ebrahimzadeh bideskan, Alireza Hosseini, Mahmoud |
author_sort | Rastegar-Moghaddam, Seyed Hamidreza |
collection | PubMed |
description | There is a complex correlation between thyroid hormones (THs) and liver function. Hypothyroidism as a failure of the thyroid gland to produce adequate thyroid hormones to fulfill the metabolic requirements of the body, may perturb liver structure and function. Emerging evidence suggests the protective effects of vitamin D against liver damage. Herein, this study aimed to investigate the role of vitamin D in hypothyroidism-associated liver injury. Forty male Wistar rats were classified into 4 groups: control, hypothyroid (Hypo) group received 0.05% PTU, Hypo- Vitamin D groups were given 100 and 500 IU/kg vitamin D orally via gavage for 6 weeks. Serum level of liver function including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) were measured. Malondialdehyde (MDA) level, superoxide dismutase (SOD) enzyme activity, and total thiol content were measured as oxidative stress indicators in the liver tissue. Furthermore, to estimate liver tissue fibrosis, Masson's trichrome staining was done. Our findings showed that hypothyroidism-induced liver fibrosis was associated with increased levels of ALT, AST and ALP. Though, vitamin D administration could significantly reduce the ALT, AST and ALP in the serum and suppress the accumulation of collagen fibers. Moreover, the activity of SOD and total thiol content was notably reduced, while the MDA content was significantly increased in the PTU- induced hypothyroid rats compared to the control group. Nonetheless, treatment with vitamin D improved mentioned oxidative stress markers in the Hypo-vitamin D groups. In conclusion, vitamin D due to its potential antioxidant and anti-fibrotic properties could be effective in the decrease of hypothyroidism-associated liver injury. |
format | Online Article Text |
id | pubmed-10428045 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-104280452023-08-17 Vitamin D alleviates hypothyroidism associated liver dysfunction: Histological and biochemical evidence Rastegar-Moghaddam, Seyed Hamidreza Akbarian, Mahsan Rajabian, Arezoo Alipour, Fatemeh Ebrahimzadeh bideskan, Alireza Hosseini, Mahmoud Heliyon Research Article There is a complex correlation between thyroid hormones (THs) and liver function. Hypothyroidism as a failure of the thyroid gland to produce adequate thyroid hormones to fulfill the metabolic requirements of the body, may perturb liver structure and function. Emerging evidence suggests the protective effects of vitamin D against liver damage. Herein, this study aimed to investigate the role of vitamin D in hypothyroidism-associated liver injury. Forty male Wistar rats were classified into 4 groups: control, hypothyroid (Hypo) group received 0.05% PTU, Hypo- Vitamin D groups were given 100 and 500 IU/kg vitamin D orally via gavage for 6 weeks. Serum level of liver function including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) were measured. Malondialdehyde (MDA) level, superoxide dismutase (SOD) enzyme activity, and total thiol content were measured as oxidative stress indicators in the liver tissue. Furthermore, to estimate liver tissue fibrosis, Masson's trichrome staining was done. Our findings showed that hypothyroidism-induced liver fibrosis was associated with increased levels of ALT, AST and ALP. Though, vitamin D administration could significantly reduce the ALT, AST and ALP in the serum and suppress the accumulation of collagen fibers. Moreover, the activity of SOD and total thiol content was notably reduced, while the MDA content was significantly increased in the PTU- induced hypothyroid rats compared to the control group. Nonetheless, treatment with vitamin D improved mentioned oxidative stress markers in the Hypo-vitamin D groups. In conclusion, vitamin D due to its potential antioxidant and anti-fibrotic properties could be effective in the decrease of hypothyroidism-associated liver injury. Elsevier 2023-08-02 /pmc/articles/PMC10428045/ /pubmed/37593614 http://dx.doi.org/10.1016/j.heliyon.2023.e18860 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Research Article Rastegar-Moghaddam, Seyed Hamidreza Akbarian, Mahsan Rajabian, Arezoo Alipour, Fatemeh Ebrahimzadeh bideskan, Alireza Hosseini, Mahmoud Vitamin D alleviates hypothyroidism associated liver dysfunction: Histological and biochemical evidence |
title | Vitamin D alleviates hypothyroidism associated liver dysfunction: Histological and biochemical evidence |
title_full | Vitamin D alleviates hypothyroidism associated liver dysfunction: Histological and biochemical evidence |
title_fullStr | Vitamin D alleviates hypothyroidism associated liver dysfunction: Histological and biochemical evidence |
title_full_unstemmed | Vitamin D alleviates hypothyroidism associated liver dysfunction: Histological and biochemical evidence |
title_short | Vitamin D alleviates hypothyroidism associated liver dysfunction: Histological and biochemical evidence |
title_sort | vitamin d alleviates hypothyroidism associated liver dysfunction: histological and biochemical evidence |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10428045/ https://www.ncbi.nlm.nih.gov/pubmed/37593614 http://dx.doi.org/10.1016/j.heliyon.2023.e18860 |
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