Cargando…

Vitamin D alleviates hypothyroidism associated liver dysfunction: Histological and biochemical evidence

There is a complex correlation between thyroid hormones (THs) and liver function. Hypothyroidism as a failure of the thyroid gland to produce adequate thyroid hormones to fulfill the metabolic requirements of the body, may perturb liver structure and function. Emerging evidence suggests the protecti...

Descripción completa

Detalles Bibliográficos
Autores principales: Rastegar-Moghaddam, Seyed Hamidreza, Akbarian, Mahsan, Rajabian, Arezoo, Alipour, Fatemeh, Ebrahimzadeh bideskan, Alireza, Hosseini, Mahmoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10428045/
https://www.ncbi.nlm.nih.gov/pubmed/37593614
http://dx.doi.org/10.1016/j.heliyon.2023.e18860
_version_ 1785090378543661056
author Rastegar-Moghaddam, Seyed Hamidreza
Akbarian, Mahsan
Rajabian, Arezoo
Alipour, Fatemeh
Ebrahimzadeh bideskan, Alireza
Hosseini, Mahmoud
author_facet Rastegar-Moghaddam, Seyed Hamidreza
Akbarian, Mahsan
Rajabian, Arezoo
Alipour, Fatemeh
Ebrahimzadeh bideskan, Alireza
Hosseini, Mahmoud
author_sort Rastegar-Moghaddam, Seyed Hamidreza
collection PubMed
description There is a complex correlation between thyroid hormones (THs) and liver function. Hypothyroidism as a failure of the thyroid gland to produce adequate thyroid hormones to fulfill the metabolic requirements of the body, may perturb liver structure and function. Emerging evidence suggests the protective effects of vitamin D against liver damage. Herein, this study aimed to investigate the role of vitamin D in hypothyroidism-associated liver injury. Forty male Wistar rats were classified into 4 groups: control, hypothyroid (Hypo) group received 0.05% PTU, Hypo- Vitamin D groups were given 100 and 500 IU/kg vitamin D orally via gavage for 6 weeks. Serum level of liver function including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) were measured. Malondialdehyde (MDA) level, superoxide dismutase (SOD) enzyme activity, and total thiol content were measured as oxidative stress indicators in the liver tissue. Furthermore, to estimate liver tissue fibrosis, Masson's trichrome staining was done. Our findings showed that hypothyroidism-induced liver fibrosis was associated with increased levels of ALT, AST and ALP. Though, vitamin D administration could significantly reduce the ALT, AST and ALP in the serum and suppress the accumulation of collagen fibers. Moreover, the activity of SOD and total thiol content was notably reduced, while the MDA content was significantly increased in the PTU- induced hypothyroid rats compared to the control group. Nonetheless, treatment with vitamin D improved mentioned oxidative stress markers in the Hypo-vitamin D groups. In conclusion, vitamin D due to its potential antioxidant and anti-fibrotic properties could be effective in the decrease of hypothyroidism-associated liver injury.
format Online
Article
Text
id pubmed-10428045
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-104280452023-08-17 Vitamin D alleviates hypothyroidism associated liver dysfunction: Histological and biochemical evidence Rastegar-Moghaddam, Seyed Hamidreza Akbarian, Mahsan Rajabian, Arezoo Alipour, Fatemeh Ebrahimzadeh bideskan, Alireza Hosseini, Mahmoud Heliyon Research Article There is a complex correlation between thyroid hormones (THs) and liver function. Hypothyroidism as a failure of the thyroid gland to produce adequate thyroid hormones to fulfill the metabolic requirements of the body, may perturb liver structure and function. Emerging evidence suggests the protective effects of vitamin D against liver damage. Herein, this study aimed to investigate the role of vitamin D in hypothyroidism-associated liver injury. Forty male Wistar rats were classified into 4 groups: control, hypothyroid (Hypo) group received 0.05% PTU, Hypo- Vitamin D groups were given 100 and 500 IU/kg vitamin D orally via gavage for 6 weeks. Serum level of liver function including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) were measured. Malondialdehyde (MDA) level, superoxide dismutase (SOD) enzyme activity, and total thiol content were measured as oxidative stress indicators in the liver tissue. Furthermore, to estimate liver tissue fibrosis, Masson's trichrome staining was done. Our findings showed that hypothyroidism-induced liver fibrosis was associated with increased levels of ALT, AST and ALP. Though, vitamin D administration could significantly reduce the ALT, AST and ALP in the serum and suppress the accumulation of collagen fibers. Moreover, the activity of SOD and total thiol content was notably reduced, while the MDA content was significantly increased in the PTU- induced hypothyroid rats compared to the control group. Nonetheless, treatment with vitamin D improved mentioned oxidative stress markers in the Hypo-vitamin D groups. In conclusion, vitamin D due to its potential antioxidant and anti-fibrotic properties could be effective in the decrease of hypothyroidism-associated liver injury. Elsevier 2023-08-02 /pmc/articles/PMC10428045/ /pubmed/37593614 http://dx.doi.org/10.1016/j.heliyon.2023.e18860 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Research Article
Rastegar-Moghaddam, Seyed Hamidreza
Akbarian, Mahsan
Rajabian, Arezoo
Alipour, Fatemeh
Ebrahimzadeh bideskan, Alireza
Hosseini, Mahmoud
Vitamin D alleviates hypothyroidism associated liver dysfunction: Histological and biochemical evidence
title Vitamin D alleviates hypothyroidism associated liver dysfunction: Histological and biochemical evidence
title_full Vitamin D alleviates hypothyroidism associated liver dysfunction: Histological and biochemical evidence
title_fullStr Vitamin D alleviates hypothyroidism associated liver dysfunction: Histological and biochemical evidence
title_full_unstemmed Vitamin D alleviates hypothyroidism associated liver dysfunction: Histological and biochemical evidence
title_short Vitamin D alleviates hypothyroidism associated liver dysfunction: Histological and biochemical evidence
title_sort vitamin d alleviates hypothyroidism associated liver dysfunction: histological and biochemical evidence
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10428045/
https://www.ncbi.nlm.nih.gov/pubmed/37593614
http://dx.doi.org/10.1016/j.heliyon.2023.e18860
work_keys_str_mv AT rastegarmoghaddamseyedhamidreza vitamindalleviateshypothyroidismassociatedliverdysfunctionhistologicalandbiochemicalevidence
AT akbarianmahsan vitamindalleviateshypothyroidismassociatedliverdysfunctionhistologicalandbiochemicalevidence
AT rajabianarezoo vitamindalleviateshypothyroidismassociatedliverdysfunctionhistologicalandbiochemicalevidence
AT alipourfatemeh vitamindalleviateshypothyroidismassociatedliverdysfunctionhistologicalandbiochemicalevidence
AT ebrahimzadehbideskanalireza vitamindalleviateshypothyroidismassociatedliverdysfunctionhistologicalandbiochemicalevidence
AT hosseinimahmoud vitamindalleviateshypothyroidismassociatedliverdysfunctionhistologicalandbiochemicalevidence