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The circadian clock protein Cryptochrome 1 is a direct target and feedback regulator of the Hippo pathway

Circadian clock controls daily behavior and physiology. The activity of various signaling pathways affects clock gene expression. Here, we show that the core circadian clock gene CRY1 is a direct target of the Hippo pathway effector YAP. YAP binds to TEADs and occupies the proximal promoter regions...

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Detalles Bibliográficos
Autores principales: Azzi, Abdelhalim, Tao, Zhipeng, Sun, Yang, Erb, Hannah, Guarino, Carla, Wu, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10428131/
https://www.ncbi.nlm.nih.gov/pubmed/37593458
http://dx.doi.org/10.1016/j.isci.2023.107449