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Fighting Antimicrobial Resistance: Insights on How the Staphylococcus aureus NorA Efflux Pump Recognizes 2-Phenylquinoline Inhibitors by Supervised Molecular Dynamics (SuMD) and Molecular Docking Simulations

[Image: see text] The superbug Staphylococcus aureus (S. aureus) exhibits several resistance mechanisms, including efflux pumps, that strongly contribute to antimicrobial resistance. In particular, the NorA efflux pump activity is associated with S. aureus resistance to fluoroquinolone antibiotics (...

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Detalles Bibliográficos
Autores principales:	Palazzotti, Deborah, Felicetti, Tommaso, Sabatini, Stefano, Moro, Stefano, Barreca, Maria Letizia, Sturlese, Mattia, Astolfi, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10428217/ https://www.ncbi.nlm.nih.gov/pubmed/37515548 http://dx.doi.org/10.1021/acs.jcim.3c00516

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