Cargando…

S125: NON-GENETIC RESISTANCE TO MENIN INHIBITION IN AML IS REVERSIBLE BY PERTURBATION OF KAT6A

Detalles Bibliográficos
Autores principales:	Perner, Florian, Rahnamoun, Homa, Wenge, Daniela V., Xiong, Yijun, Apazidis, Athina, Anand, Disha, Hatton, Charlie, Wen, Yanhe, Gu, Shengqing, Liu, X Shirley, Xiao, Wenbin, Cai, Sheng F., Levine, Ross L., Mcgeehan, Gerard M., Armstrong, Scott A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2023
Materias:	Oral Sessions
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10428331/ http://dx.doi.org/10.1097/01.HS9.0000967412.62331.23

Ejemplares similares

The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML
por: Heikamp, Emily B., et al.
Publicado: (2022)

IKAROS and MENIN Coordinate Therapeutically Actionable Leukaemogenic Gene Expression in MLL-r Acute Myeloid Leukaemia
por: Aubrey, Brandon J., et al.
Publicado: (2022)

The MLL–Menin Interaction is a Therapeutic Vulnerability in NUP98-rearranged AML
por: Rasouli, Milad, et al.
Publicado: (2023)

Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1
por: Fiskus, Warren, et al.
Publicado: (2023)

A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin–MLL Inhibition
por: Soto-Feliciano, Yadira M., et al.
Publicado: (2023)

Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)
por: Fiskus, Warren, et al.
Publicado: (2022)

PB1761: PRECLINICAL EVALUATION OF THE MENIN INHIBITOR ZIFTOMENIB IN PRIMARY AML SPECIMENS
por: Stevens, Brett, et al.
Publicado: (2023)

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism
por: Chou, Chih-Wei, et al.
Publicado: (2020)

Menin is necessary for long term maintenance of meningioma-1 driven leukemia
por: Libbrecht, Clara, et al.
Publicado: (2021)

The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia
por: Issa, Ghayas C., et al.
Publicado: (2023)

The role of menin in bone pathology
por: Gorbacheva, Anna, et al.
Publicado: (2022)

Activity of menin inhibitor ziftomenib (KO-539) as monotherapy or in combinations against AML cells with MLL1 rearrangement or mutant NPM1
por: Fiskus, Warren, et al.
Publicado: (2022)

Repressing HIF-1α-induced HDAC9 contributes to the synergistic effect of venetoclax and MENIN inhibitor in KMT2Ar AML
por: Ling, Qing, et al.
Publicado: (2023)

FBP1 Is an Interacting Partner of Menin
por: Zaman, Shadia, et al.
Publicado: (2014)

Menin: Expanding and dichotomous roles in cancer
por: Katona, Bryson W., et al.
Publicado: (2019)

The Kat in the HAT: The Histone Acetyl Transferase Kat6b (MYST4) Is Downregulated in Murine Macrophages in Response to LPS
por: Shukla, Smita, et al.
Publicado: (2018)

YBX1 mediates translation of oncogenic transcripts to control cell competition in AML
por: Perner, Florian, et al.
Publicado: (2021)

Investigating the novel-binding site of RPA2 on Menin and predicting the effect of point mutation of Menin through protein–protein interactions
por: Kaur, Gurjeet, et al.
Publicado: (2023)

Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target
por: Brzezinka, Krzysztof, et al.
Publicado: (2020)

Investigating the Effects of Amino Acid Variations in Human Menin
por: Biancaniello, Carmen, et al.
Publicado: (2022)

Hypothalamic Menin regulates systemic aging and cognitive decline
por: Leng, Lige, et al.
Publicado: (2023)

Development of an orally bioavailable selective inhibitor of the menin-MLL
por: Zhong, Hai-Jing, et al.
Publicado: (2022)

Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes
por: Sparbier, Christina E., et al.
Publicado: (2023)

KATs in Cancer: Functions and Therapies
por: Farria, Aimee, et al.
Publicado: (2015)

Multi-omics analyses of MEN1 missense mutations identify disruption of menin–MLL and menin–JunD interactions as critical requirements for molecular pathogenicity
por: Dreijerink, Koen M. A., et al.
Publicado: (2022)

Menin Links the Stress Response to Genome Stability in Drosophila melanogaster
por: Papaconstantinou, Maria, et al.
Publicado: (2010)

The Menin Tumor Suppressor Protein Is Phosphorylated in Response to DNA Damage
por: Francis, Joshua, et al.
Publicado: (2011)

Consequence of Menin Deficiency in Mouse Adipocytes Derived by In Vitro Differentiation
por: Parekh, Vaishali I., et al.
Publicado: (2015)

MON-923 MENIN Gene Mutation: Unity Amidst Diversity
por: Rais, Nadeem M, et al.
Publicado: (2020)

Loss of tumor suppressor menin expression in high grade cholangiocarcinomas
por: Lairmore, Terry C., et al.
Publicado: (2023)

HGG-24. A NOVEL ONCOGENIC ROLE FOR MENIN IN GLIOMA
por: Yang, Yanhong, et al.
Publicado: (2023)

LBODP106 Multi-omics Analyses Of MEN1 Missense Mutations Identify Disruption Of Menin-MLL And Menin-JunD Interactions As Critical Requirements For Molecular Pathogenicity
por: Dreijerink, Koen Marie Anton, et al.
Publicado: (2022)

Shock focusing phenomena: high energy density phenomena and dynamics of converging shocks
por: Apazidis, Nicholas, et al.
Publicado: (2018)

Menin Interacts with IQGAP1 to Enhance Intercellular Adhesion of β Cells
por: Yan, Jizhou, et al.
Publicado: (2008)

Menin and p53 have non-synergistic effects on tumorigenesis in mice
por: Loffler, Kelly A, et al.
Publicado: (2012)

Menin represses malignant phenotypes of melanoma through regulating multiple pathways
por: Gao, Shu-Bin, et al.
Publicado: (2011)

Characterization of High‐grade Neuroendocrine Tumors of the Lung in Relation to menin Mutations
por: Haruki, Nobuhiro, et al.
Publicado: (2000)

Menin enhances c-Myc-mediated transcription to promote cancer progression
por: Wu, Gongwei, et al.
Publicado: (2017)

miR-762 can negatively regulate menin in ovarian cancer
por: Hou, Rui, et al.
Publicado: (2017)

Menin inhibition suppresses castration-resistant prostate cancer and enhances chemosensitivity
por: Cherif, Chaïma, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_6olaq3lm5loq9ls68hleg1a4im