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Design and methodology of the SARCopenia trajectories and associations with adverse clinical outcomes in patients on HemoDialysis: the SARC-HD study
BACKGROUND: Sarcopenia has been associated with adverse outcomes in patients with chronic kidney disease (CKD), particularly in those undergoing hemodialysis (HD). However, the trajectories across sarcopenia stages, their determinants, and associations with adverse clinical outcomes have yet to be c...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10428584/ https://www.ncbi.nlm.nih.gov/pubmed/37582699 http://dx.doi.org/10.1186/s12882-023-03168-4 |
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author | Duarte, Marvery P. Pereira, Marina S. Baião, Victor M. Vieira, Fábio A. Silva, Maryanne Zilli Canedo Krug, Rodrigo R. Inda-Filho, Antônio J. Ferreira, Aparecido P. Lima, Ricardo M. Avesani, Carla Maria Nóbrega, Otávio T. Reboredo, Maycon M. Ribeiro, Heitor S. |
author_facet | Duarte, Marvery P. Pereira, Marina S. Baião, Victor M. Vieira, Fábio A. Silva, Maryanne Zilli Canedo Krug, Rodrigo R. Inda-Filho, Antônio J. Ferreira, Aparecido P. Lima, Ricardo M. Avesani, Carla Maria Nóbrega, Otávio T. Reboredo, Maycon M. Ribeiro, Heitor S. |
author_sort | Duarte, Marvery P. |
collection | PubMed |
description | BACKGROUND: Sarcopenia has been associated with adverse outcomes in patients with chronic kidney disease (CKD), particularly in those undergoing hemodialysis (HD). However, the trajectories across sarcopenia stages, their determinants, and associations with adverse clinical outcomes have yet to be comprehensively examined. METHODS: The SARC-HD is a multicenter, observational prospective cohort study designed to comprehensively investigate sarcopenia in patients on HD. Eligibility criteria include adult patients undergoing HD for ≥ 3 months. The primary objective is to investigate the trajectories of sarcopenia stages and their potential determinants. Secondary objectives include evaluating the association between sarcopenia and adverse clinical outcomes (i.e., falls, hospitalization, and mortality). Sarcopenia risk will be assessed by the SARC-F and SARC-CalF questionnaire. Sarcopenia traits (i.e., low muscle strength, low muscle mass, and low physical performance) will be defined according to the revised European Working Group on Sarcopenia in Older People and will be assessed at baseline and after 12 follow-up months. Patients will be followed-up at 3 monthly intervals for adverse clinical outcomes during 24 months. DISCUSSION: Collectively, we expect to provide relevant clinical findings for healthcare professionals from nephrology on the association between sarcopenia screening tools (i.e., SARC-F and SARC-CalF) with objective sarcopenia measurements, as well as to investigate predictors of trajectories across sarcopenia stages, and the impact of sarcopenia on adverse clinical outcomes. Hence, our ambition is that the data acquired from SARC-HD study will provide novel and valuable evidence to support an adequate screening and management of sarcopenia in patients on HD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12882-023-03168-4. |
format | Online Article Text |
id | pubmed-10428584 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-104285842023-08-17 Design and methodology of the SARCopenia trajectories and associations with adverse clinical outcomes in patients on HemoDialysis: the SARC-HD study Duarte, Marvery P. Pereira, Marina S. Baião, Victor M. Vieira, Fábio A. Silva, Maryanne Zilli Canedo Krug, Rodrigo R. Inda-Filho, Antônio J. Ferreira, Aparecido P. Lima, Ricardo M. Avesani, Carla Maria Nóbrega, Otávio T. Reboredo, Maycon M. Ribeiro, Heitor S. BMC Nephrol Study Protocol BACKGROUND: Sarcopenia has been associated with adverse outcomes in patients with chronic kidney disease (CKD), particularly in those undergoing hemodialysis (HD). However, the trajectories across sarcopenia stages, their determinants, and associations with adverse clinical outcomes have yet to be comprehensively examined. METHODS: The SARC-HD is a multicenter, observational prospective cohort study designed to comprehensively investigate sarcopenia in patients on HD. Eligibility criteria include adult patients undergoing HD for ≥ 3 months. The primary objective is to investigate the trajectories of sarcopenia stages and their potential determinants. Secondary objectives include evaluating the association between sarcopenia and adverse clinical outcomes (i.e., falls, hospitalization, and mortality). Sarcopenia risk will be assessed by the SARC-F and SARC-CalF questionnaire. Sarcopenia traits (i.e., low muscle strength, low muscle mass, and low physical performance) will be defined according to the revised European Working Group on Sarcopenia in Older People and will be assessed at baseline and after 12 follow-up months. Patients will be followed-up at 3 monthly intervals for adverse clinical outcomes during 24 months. DISCUSSION: Collectively, we expect to provide relevant clinical findings for healthcare professionals from nephrology on the association between sarcopenia screening tools (i.e., SARC-F and SARC-CalF) with objective sarcopenia measurements, as well as to investigate predictors of trajectories across sarcopenia stages, and the impact of sarcopenia on adverse clinical outcomes. Hence, our ambition is that the data acquired from SARC-HD study will provide novel and valuable evidence to support an adequate screening and management of sarcopenia in patients on HD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12882-023-03168-4. BioMed Central 2023-08-15 /pmc/articles/PMC10428584/ /pubmed/37582699 http://dx.doi.org/10.1186/s12882-023-03168-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Study Protocol Duarte, Marvery P. Pereira, Marina S. Baião, Victor M. Vieira, Fábio A. Silva, Maryanne Zilli Canedo Krug, Rodrigo R. Inda-Filho, Antônio J. Ferreira, Aparecido P. Lima, Ricardo M. Avesani, Carla Maria Nóbrega, Otávio T. Reboredo, Maycon M. Ribeiro, Heitor S. Design and methodology of the SARCopenia trajectories and associations with adverse clinical outcomes in patients on HemoDialysis: the SARC-HD study |
title | Design and methodology of the SARCopenia trajectories and associations with adverse clinical outcomes in patients on HemoDialysis: the SARC-HD study |
title_full | Design and methodology of the SARCopenia trajectories and associations with adverse clinical outcomes in patients on HemoDialysis: the SARC-HD study |
title_fullStr | Design and methodology of the SARCopenia trajectories and associations with adverse clinical outcomes in patients on HemoDialysis: the SARC-HD study |
title_full_unstemmed | Design and methodology of the SARCopenia trajectories and associations with adverse clinical outcomes in patients on HemoDialysis: the SARC-HD study |
title_short | Design and methodology of the SARCopenia trajectories and associations with adverse clinical outcomes in patients on HemoDialysis: the SARC-HD study |
title_sort | design and methodology of the sarcopenia trajectories and associations with adverse clinical outcomes in patients on hemodialysis: the sarc-hd study |
topic | Study Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10428584/ https://www.ncbi.nlm.nih.gov/pubmed/37582699 http://dx.doi.org/10.1186/s12882-023-03168-4 |
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