Warburg effect enhanced by AKR1B10 promotes acquired resistance to pemetrexed in lung cancer-derived brain metastasis

BACKGROUND: Resistance to pemetrexed (PEM), a rare chemotherapeutic agent that can efficiently cross the blood-brain barrier, limits the therapeutic efficacy for patients with lung cancer brain metastasis (BM). Aldo-keto reductase family 1 B10 (AKR1B10) was recently found to be elevated in lung canc...

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Detalles Bibliográficos
Autores principales: Duan, Wenzhe, Liu, Wenwen, Xia, Shengkai, Zhou, Yang, Tang, Mengyi, Xu, Mingxin, Lin, Manqing, Li, Xinyu, Wang, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10428599/
https://www.ncbi.nlm.nih.gov/pubmed/37587486
http://dx.doi.org/10.1186/s12967-023-04403-0

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