Heart rate reduction after genetic ablation of L-type Ca(v)1.3 channels induces cardioprotection against ischemia-reperfusion injury

BACKGROUND: Acute myocardial infarction (AMI) is the major cause of cardiovascular mortality worldwide. Most ischemic episodes are triggered by an increase in heart rate, which induces an imbalance between myocardial oxygen delivery and consumption. Developing drugs that selectively reduce heart rat...

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Detalles Bibliográficos
Autores principales: Delgado-Betancourt, Viviana, Chinda, Kroekkiat, Mesirca, Pietro, Barrère, Christian, Covinhes, Aurélie, Gallot, Laura, Vincent, Anne, Bidaud, Isabelle, Kumphune, Sarawut, Nargeot, Joël, Piot, Christophe, Wickman, Kevin, Mangoni, Matteo Elia, Barrère-Lemaire, Stéphanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10429177/
https://www.ncbi.nlm.nih.gov/pubmed/37593151
http://dx.doi.org/10.3389/fcvm.2023.1134503

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