Procalcitonin levels in maternal serum and cord blood as marker for diagnosis of early onset neonatal sepsis

OBJECTIVES: To assess the diagnostic accuracy of Procalcitonin in maternal serum and umbilical cord blood samples to predict Early onset neonatal sepsis (EONS). STUDY DESIGN: It was a Prospective analytical cohort study. Pregnant women ≥ 34 weeks gestation in active labour, with risk factors for EON...

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Autores principales: Yadav, Puja, Agarwal, Kavita, Rani, Anita, Dewan, Rupali, Chellani, Harish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Obstetrics and Maternal Fetal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10430163/
https://www.ncbi.nlm.nih.gov/pubmed/37593584
http://dx.doi.org/10.1016/j.eurox.2023.100221
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author Yadav, Puja
Agarwal, Kavita
Rani, Anita
Dewan, Rupali
Chellani, Harish
author_facet Yadav, Puja
Agarwal, Kavita
Rani, Anita
Dewan, Rupali
Chellani, Harish
author_sort Yadav, Puja
collection PubMed
description OBJECTIVES: To assess the diagnostic accuracy of Procalcitonin in maternal serum and umbilical cord blood samples to predict Early onset neonatal sepsis (EONS). STUDY DESIGN: It was a Prospective analytical cohort study. Pregnant women ≥ 34 weeks gestation in active labour, with risk factors for EONS were included in the study. Maternal blood samples at recruitment and umbilical cord blood samples after delivery were taken for Total leucocyte count (TLC), high sensitivity C-Reactive Protein (hs-CRP) and Procalcitonin. Newborns were classified into non-infected, suspected and proven infection. Sensitivity, specificity and diagnostic accuracy of maternal and cord blood procalcitonin, TLC and hs-CRP were calculated. RESULTS: A total of 200 women were recruited. Maternal procalcitonin had a superior diagnostic accuracy of 99% compared to maternal TLC and maternal hs-CRP. Also, cord blood procalcitonin had a diagnostic accuracy of 95%. CONCLUSION: Procalcitonin in both maternal as well as cord blood is a promising biomarker to detect EONS with high diagnostic accuracy.
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spelling pubmed-104301632023-08-17 Procalcitonin levels in maternal serum and cord blood as marker for diagnosis of early onset neonatal sepsis Yadav, Puja Agarwal, Kavita Rani, Anita Dewan, Rupali Chellani, Harish Eur J Obstet Gynecol Reprod Biol X Obstetrics and Maternal Fetal Medicine OBJECTIVES: To assess the diagnostic accuracy of Procalcitonin in maternal serum and umbilical cord blood samples to predict Early onset neonatal sepsis (EONS). STUDY DESIGN: It was a Prospective analytical cohort study. Pregnant women ≥ 34 weeks gestation in active labour, with risk factors for EONS were included in the study. Maternal blood samples at recruitment and umbilical cord blood samples after delivery were taken for Total leucocyte count (TLC), high sensitivity C-Reactive Protein (hs-CRP) and Procalcitonin. Newborns were classified into non-infected, suspected and proven infection. Sensitivity, specificity and diagnostic accuracy of maternal and cord blood procalcitonin, TLC and hs-CRP were calculated. RESULTS: A total of 200 women were recruited. Maternal procalcitonin had a superior diagnostic accuracy of 99% compared to maternal TLC and maternal hs-CRP. Also, cord blood procalcitonin had a diagnostic accuracy of 95%. CONCLUSION: Procalcitonin in both maternal as well as cord blood is a promising biomarker to detect EONS with high diagnostic accuracy. Elsevier 2023-07-30 /pmc/articles/PMC10430163/ /pubmed/37593584 http://dx.doi.org/10.1016/j.eurox.2023.100221 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Obstetrics and Maternal Fetal Medicine
Yadav, Puja
Agarwal, Kavita
Rani, Anita
Dewan, Rupali
Chellani, Harish
Procalcitonin levels in maternal serum and cord blood as marker for diagnosis of early onset neonatal sepsis
title Procalcitonin levels in maternal serum and cord blood as marker for diagnosis of early onset neonatal sepsis
title_full Procalcitonin levels in maternal serum and cord blood as marker for diagnosis of early onset neonatal sepsis
title_fullStr Procalcitonin levels in maternal serum and cord blood as marker for diagnosis of early onset neonatal sepsis
title_full_unstemmed Procalcitonin levels in maternal serum and cord blood as marker for diagnosis of early onset neonatal sepsis
title_short Procalcitonin levels in maternal serum and cord blood as marker for diagnosis of early onset neonatal sepsis
title_sort procalcitonin levels in maternal serum and cord blood as marker for diagnosis of early onset neonatal sepsis
topic Obstetrics and Maternal Fetal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10430163/
https://www.ncbi.nlm.nih.gov/pubmed/37593584
http://dx.doi.org/10.1016/j.eurox.2023.100221
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