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Advancements in Marburg (MARV) Virus Vaccine Research With Its Recent Reemergence in Equatorial Guinea and Tanzania: A Scoping Review

Given the recent outbreaks of the Marburg (MARV) virus within the first quarter of the year 2023, interest in the MARV virus has been re-ignited given its shared phylogeny with the dreadful Ebola virus. This relation gives some insight into its virulence, associated morbidities, and mortality rates....

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Autores principales: Mane Manohar, Manish P, Lee, Vivian J, Chinedum Odunukwe, Ejikeme U, Singh, Pratik K, Mpofu, Buhlebethu S, Oxley, MD, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10430785/
https://www.ncbi.nlm.nih.gov/pubmed/37593293
http://dx.doi.org/10.7759/cureus.42014
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author Mane Manohar, Manish P
Lee, Vivian J
Chinedum Odunukwe, Ejikeme U
Singh, Pratik K
Mpofu, Buhlebethu S
Oxley, MD, Christine
author_facet Mane Manohar, Manish P
Lee, Vivian J
Chinedum Odunukwe, Ejikeme U
Singh, Pratik K
Mpofu, Buhlebethu S
Oxley, MD, Christine
author_sort Mane Manohar, Manish P
collection PubMed
description Given the recent outbreaks of the Marburg (MARV) virus within the first quarter of the year 2023, interest in the MARV virus has been re-ignited given its shared phylogeny with the dreadful Ebola virus. This relation gives some insight into its virulence, associated morbidities, and mortality rates. The first outbreak of MARV recorded was in Germany, in 1967, of which seven died out of 31 reported cases. Ever since, subsequent cases have been reported all over Africa, a continent replete with failing healthcare systems.  This reality impresses a need for a contemporary and concise revision of the MARV virus existing publications especially in the areas of vaccine research. A functional MARV vaccine will serve as a panacea to ailing communities within the African healthcare landscape.  The objective of this scoping review is to provide pertinent information relating to MARV vaccine research beginning with an outline of MARV’s pathology and pathogenesis in addition to the related morbidities, existing therapies, established outbreak protocols as well as areas of opportunities.
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spelling pubmed-104307852023-08-17 Advancements in Marburg (MARV) Virus Vaccine Research With Its Recent Reemergence in Equatorial Guinea and Tanzania: A Scoping Review Mane Manohar, Manish P Lee, Vivian J Chinedum Odunukwe, Ejikeme U Singh, Pratik K Mpofu, Buhlebethu S Oxley, MD, Christine Cureus Infectious Disease Given the recent outbreaks of the Marburg (MARV) virus within the first quarter of the year 2023, interest in the MARV virus has been re-ignited given its shared phylogeny with the dreadful Ebola virus. This relation gives some insight into its virulence, associated morbidities, and mortality rates. The first outbreak of MARV recorded was in Germany, in 1967, of which seven died out of 31 reported cases. Ever since, subsequent cases have been reported all over Africa, a continent replete with failing healthcare systems.  This reality impresses a need for a contemporary and concise revision of the MARV virus existing publications especially in the areas of vaccine research. A functional MARV vaccine will serve as a panacea to ailing communities within the African healthcare landscape.  The objective of this scoping review is to provide pertinent information relating to MARV vaccine research beginning with an outline of MARV’s pathology and pathogenesis in addition to the related morbidities, existing therapies, established outbreak protocols as well as areas of opportunities. Cureus 2023-07-17 /pmc/articles/PMC10430785/ /pubmed/37593293 http://dx.doi.org/10.7759/cureus.42014 Text en Copyright © 2023, Mane Manohar et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Infectious Disease
Mane Manohar, Manish P
Lee, Vivian J
Chinedum Odunukwe, Ejikeme U
Singh, Pratik K
Mpofu, Buhlebethu S
Oxley, MD, Christine
Advancements in Marburg (MARV) Virus Vaccine Research With Its Recent Reemergence in Equatorial Guinea and Tanzania: A Scoping Review
title Advancements in Marburg (MARV) Virus Vaccine Research With Its Recent Reemergence in Equatorial Guinea and Tanzania: A Scoping Review
title_full Advancements in Marburg (MARV) Virus Vaccine Research With Its Recent Reemergence in Equatorial Guinea and Tanzania: A Scoping Review
title_fullStr Advancements in Marburg (MARV) Virus Vaccine Research With Its Recent Reemergence in Equatorial Guinea and Tanzania: A Scoping Review
title_full_unstemmed Advancements in Marburg (MARV) Virus Vaccine Research With Its Recent Reemergence in Equatorial Guinea and Tanzania: A Scoping Review
title_short Advancements in Marburg (MARV) Virus Vaccine Research With Its Recent Reemergence in Equatorial Guinea and Tanzania: A Scoping Review
title_sort advancements in marburg (marv) virus vaccine research with its recent reemergence in equatorial guinea and tanzania: a scoping review
topic Infectious Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10430785/
https://www.ncbi.nlm.nih.gov/pubmed/37593293
http://dx.doi.org/10.7759/cureus.42014
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